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This page gives details of CPPsite entry with ID 2581
Primary information
CPPsite ID2581
PEPTIDE SEQUENCERRRQRRKKRGYCKCKYGRKKRRQRRR
PEPTIDE NAMEdfTAT
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytosol and Nucleus
N-TERMINAL MODIFICATIONExtra Cys and Lys added for labeling of TMR and dimerization
C-TERMINAL MODIFICATIONFree
PROPOSED UPTAKE MECHANISMMacropinocytosis
INVITRO/INVIVOIn vitro
CELL LINEHeLa, Neuro-2a and HDF cells
CARGOProtein (eGFP), Fluorophore (TMR)
PMID24930129
PATENTUnknown
LENGTH26
Secondary StructureCHHHHTCCCSSSGGGCSTHHHHHHTC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH
Tertiary Structure
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  (PEPstrMOD)