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This page gives details of CPPsite entry with ID 2580 |
| Primary information | |
|---|---|
| CPPsite ID | 2580 |
| PEPTIDE SEQUENCE | CKYGRKKRRQRRR |
| PEPTIDE NAME | fTAT |
| CHIRALITY | L |
| LINEAR/CYCLIC | Linear |
| SOURCE | Protein derived |
| CATEGORY | Cationic |
| SUB CELLULAR LOCALIZATION | Vesicles |
| N-TERMINAL MODIFICATION | Extra Cys and Lys added for labeling of TMR |
| C-TERMINAL MODIFICATION | Free |
| UPTAKE EFFICIENCY | dfTAT accumulates inside endosomes already containing DEAC-K9 and that dfTAT endosomal escape is also accompanied by the leakage of luminal DEAC-K9 |
| PROPOSED UPTAKE MECHANISM | Macropinocytosis |
| INVITRO/INVIVO | In vitro |
| CELL LINE | HeLa, Neuro-2a and HDF cells |
| CARGO | Fluorophore (TMR) |
| PMID | 24930129 |
| PATENT | Unknown |
| LENGTH | 13 |
| Secondary Structure | CCCCTTCGGGGGC |
| SMILES | N[C@@H](CS)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O |
| Tertiary Structure (Technique) | View in Jmol OR Download Structure (PEPstrMOD) |