Welcome to Entry Card of Peptide


This page gives details of CPPsite entry with ID 2558
Primary information
CPPsite ID2558
PEPTIDE SEQUENCEGRKKRRQRRR
PEPTIDE NAMETm3+-DOTA-CAT
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
N-TERMINAL MODIFICATIONConjugated with Tm³⁺-DOTA via CAT recognition site
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYCat-D expression increases uptake of Tm3+-DOTA-CAT in neuronal SN56 cells
INVITRO/INVIVOIn vitro and in vivo
CELL LINESN56 cells
In VIVO MODELAPP/PS1-dE9 mice
CARGOMRI probe [DOTA-caged metal ion (Tm³?)]
PMID23281285
PATENTUnknown
LENGTH10
Secondary StructureCCHHHHGGGC
SMILESNCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)