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This page gives details of CPPsite entry with ID 2487
Primary information
CPPsite ID2487
PEPTIDE SEQUENCEIRQRRRR
PEPTIDE NAMEIRQ
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONConjugation to solid lipid nanoparticle
UPTAKE EFFICIENCYShowed significantly higher drug internalization than that of unmodified ones
PROPOSED UPTAKE MECHANISMBoth clathrin- and caveolae-dependent endocytosis
INVITRO/INVIVOIn vitro and in vivo
CELL LINECaco-2 cells and goblet like HT29-MTX cells
In VIVO MODELMale Sprague-Dawley rats
CARGOProtein (FITC-sCT), Nanoparticle( SLN)
PMID24968819
PATENTUnknown
LENGTH7
Secondary StructureCCSCCCC
SMILESN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)