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This page gives details of CPPsite entry with ID 2469
Primary information
CPPsite ID2469
PEPTIDE SEQUENCEWEARLARALARALARHLARALARALRACEA
PEPTIDE NAMERALA
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic and amphipathic
SUB CELLULAR LOCALIZATIONNucleus
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYRALA/pDNA nanoparticles in vitro is comparable with commercial transfecting agents while exhibiting significantly lower cytotoxicity
PROPOSED UPTAKE MECHANISMEndocytic pathway
INVITRO/INVIVOIn vitro and in vivo
CELL LINEZR-75-1, PC-3 and NCTC-929
In VIVO MODELFemale C57BL/6 mice
CARGONanoparticle (Cy3-labeled nanoparticles complexed with DNA)
PMID24995949
PATENTUnknown
LENGTH30
Secondary StructureCCSTTHHHHTTTHHHHHHHHHHHHHTSSCC
SMILESN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@
Tertiary Structure
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  (PEPstrMOD)