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This page gives details of CPPsite entry with ID 2437
Primary information
CPPsite ID2437
PEPTIDE SEQUENCERRRRWWWW
PEPTIDE NAME[R4W4]Cyclic
CHIRALITYL
LINEAR/CYCLICCyclic
SOURCESynthetic
CATEGORYPositive charge and hydrophobic moiety, amphiphilic
SUB CELLULAR LOCALIZATIONCytosol and Nucleus
N-TERMINAL MODIFICATIONConjugation with fluorescein
C-TERMINAL MODIFICATIONCyclization
UPTAKE EFFICIENCYHigher uptake efficiency
PROPOSED UPTAKE MECHANISMMultiple pathways pathways
INVITRO/INVIVOIn vitro
CELL LINESK-OV-3 cells
CARGOFluorophore (Fluorescein)
PMID25157458
PATENTUnknown
LENGTH8
Secondary StructureCCCCSSCC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)CO
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)