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This page gives details of CPPsite entry with ID 2335
Primary information
CPPsite ID2335
PEPTIDE SEQUENCECELAGIGILTVRKKRRQRRR
PEPTIDE NAMEAlexa488-Melan-A-TAT
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEChimeric
CATEGORYCationic
SUB CELLULAR LOCALIZATIONLysosome
N-TERMINAL MODIFICATIONConjugation with Alexa488 C5 maleimide
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYHigher uptake efficiency
PROPOSED UPTAKE MECHANISMClathrin-mediated endocytosis
INVITRO/INVIVOIn vitro
CELL LINEDCs, HUVECs and Jurkat cells
CARGOFluorophore (Alexa488) and Protein (ovalbumin)
PMID24372650
PATENTUnknown
LENGTH20
Secondary StructureCCSSTTTSSTTTTTCCSSCC
SMILESN[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)