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This page gives details of CPPsite entry with ID 2210
Primary information
CPPsite ID2210
PEPTIDE SEQUENCERRWRRWWRRWWRRWRR
PEPTIDE NAMERW16
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYAmphipathic
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYNumber of protrusions observed when PMS were incubated with the longer amphipathic peptide RW16 was smaller compared to RW9
PROPOSED UPTAKE MECHANISMEndocytosis, direct translocation or physical endocytosis
INVITRO/INVIVOIn vitro
CELL LINEStandard and Annexin 2-GFP transfected MDCK cells
CARGONanoparticle (PMS labelled with the fluorescent probe di-4-ANEPPDHQ)
PMID24583633
PATENTUnknown
LENGTH16
Secondary StructureCGGGGTHHHHHHHHTC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)