This page gives details of CPPsite entry with ID 2210 |
Primary information | |
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CPPsite ID | 2210 |
PEPTIDE SEQUENCE | RRWRRWWRRWWRRWRR |
PEPTIDE NAME | RW16 |
CHIRALITY | L |
LINEAR/CYCLIC | Linear |
SOURCE | Synthetic |
CATEGORY | Amphipathic |
N-TERMINAL MODIFICATION | Free |
C-TERMINAL MODIFICATION | Free |
UPTAKE EFFICIENCY | Number of protrusions observed when PMS were incubated with the longer amphipathic peptide RW16 was smaller compared to RW9 |
PROPOSED UPTAKE MECHANISM | Endocytosis, direct translocation or physical endocytosis |
INVITRO/INVIVO | In vitro |
CELL LINE | Standard and Annexin 2-GFP transfected MDCK cells |
CARGO | Nanoparticle (PMS labelled with the fluorescent probe di-4-ANEPPDHQ) |
PMID | 24583633 |
PATENT | Unknown |
LENGTH | 16 |
Secondary Structure | CGGGGTHHHHHHHHTC |
SMILES | N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O |
Tertiary Structure (Technique) | View in Jmol  OR Download Structure (PEPstrMOD) |