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This page gives details of CPPsite entry with ID 2188
Primary information
CPPsite ID2188
PEPTIDE SEQUENCEKCFQWQRNMRKVRGPPVSCIKR
PEPTIDE NAMEhLF +4R
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytosol and Nucleus
N-TERMINAL MODIFICATIONConjugation with 5(6)-Carboxyfluorescein
C-TERMINAL MODIFICATIONAmidation
UPTAKE EFFICIENCYHigher than hLF Wt
PROPOSED UPTAKE MECHANISMEndocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ)
INVITRO/INVIVOIn vitro
CELL LINEHeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells
CARGOFluorophore (Fluorescein)
PMID24270856
PATENTUnknown
LENGTH22
Secondary StructureCCHHHHHHHHTTTSCTTSGGGC
SMILESN[C@@H](CCCC[NH3])C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)