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This page gives details of CPPsite entry with ID 2168
Primary information
CPPsite ID2168
PEPTIDE SEQUENCEIRQRRRR
PEPTIDE NAMEIRQ
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONFree
CHEMICAL MODIFICATIONCoupling to polyoxyethylene (40) steartae (SA-PEG2000)
UPTAKE EFFICIENCYIRQ modified SLNs showed better drug protection ability
PROPOSED UPTAKE MECHANISMClathrin- and caveolae-dependent endocytosis
INVITRO/INVIVOIn vitro and in vivo
CELL LINECaco-2/HT29-MTX
In VIVO MODELMale Sprague-Dawley rats
CARGONanoparticle [salmon calcitonin (sCT)-loaded SLNs (Solid Lipid Nanoparticle)]
PMID24968819
PATENTUnknown
LENGTH7
Secondary StructureCCSCCCC
SMILESN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)