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This page gives details of CPPsite entry with ID 2163
Primary information
CPPsite ID2163
PEPTIDE SEQUENCEWEARLARALARALARHLARALARA
PEPTIDE NAMERALA peptide
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYAmphipathic
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYReadily traversed the plasma membrane of both cancer and fibroblast cell lines and elicited reporter-gene expression following intravenous delivery in vivo
PROPOSED UPTAKE MECHANISMEndocytosis
INVITRO/INVIVOIn vitro and in vivo
CELL LINEZR-75-1 human breast cancer, PC-3 human prostate cancerand NCTC-929 murine fibroblast cell lines
CARGONucleic acid (pDNA)
PMID24995949
PATENTUnknown
LENGTH24
Secondary StructureCCTTTHHHHHHHHHHHHHHHHHCC
SMILESN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)CO
Tertiary Structure
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  (PEPstrMOD)