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This page gives details of CPPsite entry with ID 2137
Primary information
CPPsite ID2137
PEPTIDE SEQUENCEHHHHHHHHHHHHRRRRRRRRRRRRRRR
PEPTIDE NAMESTR-H12R8
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONStearylation
C-TERMINAL MODIFICATIONAmidation
UPTAKE EFFICIENCYSTR-H12R8 induced gene silencing with the knockdown efficiency of 31% at R/P 5 and 59% at R/P 10
PROPOSED UPTAKE MECHANISMEndocytosis
INVITRO/INVIVOIn vitro
CELL LINECHO-K1 cells, HeLa
CARGONucleic acid (GAPDH siRNA)
PMID25193363
PATENTUnknown
LENGTH27
Secondary StructureCCCCCSSSCSCSSGGGCTTHHHHTTCC
SMILESN[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@
Tertiary Structure
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