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This page gives details of CPPsite entry with ID 1833
Primary information
CPPsite ID1833
PEPTIDE SEQUENCERRRRNRTRRNRRRVRGC
PEPTIDE NAMEFHV coat (35-49)
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONPunctate distribution (vesicles) with diffuse flurescence in cytosole and
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONConjugation with Alexa 488 at glycyl cysteine sequence
UPTAKE EFFICIENCY2.7–6.4 times more than the Rev peptide
PROPOSED UPTAKE MECHANISMEndocytic pathway (Macropinocytosis)
INVITRO/INVIVOIn vitro
CELL LINECHO-K1, HeLa and Jurkat
CARGOFluorophore (Alexa-488)
PMID19707187
PATENTUnknown
LENGTH17
Secondary StructureCTTTCSSSSCCSSSSCC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CS)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)