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This page gives details of CPPsite entry with ID 1212
Primary information
CPPsite ID1212
PEPTIDE SEQUENCEVKRGLKLRHVRPRVTRMDV
PEPTIDE NAMEDPV1047
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYUnknown
SUB CELLULAR LOCALIZATIONNucleus
N-TERMINAL MODIFICATIONCys addition
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYLower than other DPVs and tat (48-60)
PROPOSED UPTAKE MECHANISMEnergy-dependent caveolar endocytic independent mechanism
INVITRO/INVIVOIn vitro
CELL LINEHeLa, HCT116, HL-60, K562, Molt4, NIH-3T3 and primary hepatocyte cultures
CARGOProtein (PO and IgG)
PMID15859953
PATENTUnknown
LENGTH19
Secondary StructureCEESSSEECCTTTSCCTTC
SMILESN[C@@H](C(C)C)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C=O
Tertiary Structure
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  (PEPstrMOD)