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This page gives details of CPPsite entry with ID 1206
Primary information
CPPsite ID1206
PEPTIDE SEQUENCERKKRRRESRKKRRRES
PEPTIDE NAMEDPV3
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYUnknown
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONCys addition
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYHigher than other DPVs and Tat (48-60)
PROPOSED UPTAKE MECHANISMEnergy-dependent endocytic process involving cell membrane lipid rafts
INVITRO/INVIVOIn vitro
CELL LINEHeLa, HCT116, HL-60, K562, Molt4, NIH-3T3 and primary hepatocyte cultures
CARGOProtein (PO and IgG)
PMID15859953
PATENTUnknown
LENGTH16
Secondary StructureCGGGGSTHHHHTTCCC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C=O
Tertiary Structure
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  (PEPstrMOD)