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This page gives details of CPPsite entry with ID 1020
Primary information
CPPsite ID1020
PEPTIDE SEQUENCERKKRRQARR
PEPTIDE NAMEAla55 substitution mutant of Tat (49-57)
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONProbably cytoplasm and nucleus, nucleolus
N-TERMINAL MODIFICATIONConjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYLow (relative to Tat (49-57))
PROPOSED UPTAKE MECHANISMProbably non-endocytic pathway
INVITRO/INVIVOIn vitro
CELL LINEJurkat
CARGOFluorophore (fluorescein)
PMID11087855
PATENTUS 6593292
LENGTH9
Secondary StructureCGGGTTTCC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)