Welcome to Entry Card of Peptide


This page gives details of CPPsite entry with ID 1016
Primary information
CPPsite ID1016
PEPTIDE SEQUENCERKARRQRRR
PEPTIDE NAMEAla51 substitution mutant of Tat (49-57)
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONProbably cytoplasm and nucleus, nucleolus
N-TERMINAL MODIFICATIONConjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYLow (relative to Tat (49-57))
PROPOSED UPTAKE MECHANISMProbably non-endocytic pathway
INVITRO/INVIVOIn vitro
CELL LINEJurkat
CARGOFluorophore (fluorescein)
PMID11087855
PATENTUS 6593292
LENGTH9
Secondary StructureCTTTTTTTC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)