This page gives details of CPPsite entry with ID 1002 |
Primary information | |
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CPPsite ID | 1002 |
PEPTIDE SEQUENCE | LGISYGRKKRRQRRRPPQ |
PEPTIDE NAME | Tat (43-60) |
CHIRALITY | L |
LINEAR/CYCLIC | Linear |
SOURCE | Protein derived |
CATEGORY | Cationic |
SUB CELLULAR LOCALIZATION | Cytoplasm and nucleus, nucelolus |
N-TERMINAL MODIFICATION | Labelled with Cys-acetamidomethyl |
C-TERMINAL MODIFICATION | Conjugation with fluorescein maleimide |
UPTAKE EFFICIENCY | High |
PROPOSED UPTAKE MECHANISM | Non-endocytic pathway |
INVITRO/INVIVO | In vitro |
CELL LINE | HeLa |
CARGO | Fluorophore (fluorescein) |
PMID | 9188504 |
PATENT | US 6740524 |
LENGTH | 18 |
Secondary Structure | CCCCSSTTGGGGGSCSCC |
SMILES | N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C=O |
Tertiary Structure (Technique) | View in Jmol  OR Download Structure (PEPstrMOD) |