In the past years, many tools have been developed to identify whether a given sequence is a linear epitope but these tools cannot able to detect whether the epitope is IgG, IgE, or IgA. Fewer number of tools are available that can predict the sub-type of an epitope listed below.

Name Year Description Pubmed ID
IgPred 2013 Identification of B-cell epitopes in an antigen for inducing specific class of antibodies/AAC, AAP, CTD, DPC, PCP, BIN 24168386
Lyra 2015 The LYRA server predicts structures for either T-Cell Receptors (TCR) or B-Cell Receptors (BCR) using homology modelling/Canonical structure method 26007650
NIgPred 2021 Class-Specific Antibody Prediction for Linear B-Cell Epitopes Based on Heterogeneous Features and Machine-Learning Approaches/Composition, physico-chemical, autocorrelation, and peptide-characteristic correlation features. 34452396
AbCPE 2021 Antibody Class(es) Predictor for Epitopes (AbCPE): A Multi-Label Classification Algorithm/DPC, AAC, PseAAC 36303781
EPIPRED 2014 Improving B-cell epitope prediction and its application to global antibody-antigen docking/Structure-based method (ASEP, Docking) 24753488
PEASE 2015 PEASE: predicting B-cell epitopes utilizing antibody sequence/Structure-based method (ASEP, ML) 25432167