Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_1223
Primary information
B3PDB IDb3pdb_1223
Peptide NameD-penetratin
PEPTIDE SEQUENCE (1-letter)RQIKIWFQNRRMKWKK
PEPTIDE SEQUENCE (3-letter)NA
N-terminal modificationNA
C-terminal modificationNA
Chemical modificationNA
Peptide Length16
ConformationNA
Peptide NatureNA
Source/Origin of peptideChemically synthesized
SMILESNA
Cell LineIn situ brain perfusion technique
In vitro CONCENTRATIONNA
In vitro METHODCapillary depletion method
In vitro RESULTVectorization of dox led to a 20-fold increase in the amount of dox transportation.
ANIMAL MODELMale Sprague-Dawley rats
In vivo CONCENTRATION2.5 mg/kg
In vivo MODE OF DELIVERYIntravenous
In vivo METHODCapillary depletion method
In vivo RESULTIt led to a significant increase in brain dox concentrations during the first 30 min of postadminist
ACTIONThe use of these peptide vectors for brain delivery of dox.
TRANSPORT TYPETranscytosis
SUBCELLULAR LOCALISATIONBrain parenchyma
COMBINATIONCombined with Doxorubicin
PHYSICAL CONDITIONNA
RESPONSENA
RESULTNA
LABELNA
PMID10727512