Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_1210
Primary information
B3PDB IDb3pdb_1210
Peptide NamePHT-TGN-HBc
PEPTIDE SEQUENCE (1-letter)TGNYKALHPHNG
PEPTIDE SEQUENCE (3-letter)NA
N-terminal modificationNA
C-terminal modificationNA
Chemical modificationNA
Peptide Length12
ConformationLinear
Peptide NatureNA
Source/Origin of peptideChemically synthesized
SMILESNA
Cell LineHuman astrocytes HA1800
In vitro CONCENTRATION0.2 mg PHT/kg
In vitro METHODConfocal Microscopy
In vitro RESULTNA
ANIMAL MODELMice
In vivo CONCENTRATION0.2 mg PHT/kg
In vivo MODE OF DELIVERYIntravenous
In vivo METHODVIS Lumina II Spectrum Imaging System
In vivo RESULTIt demonstrated high penetration ability
ACTIONPHT-TGN-HBc NCs showed high antiepileptic effects in epilepsy mouse model with no side effects
TRANSPORT TYPEPermeability
SUBCELLULAR LOCALISATIONCerebral vasculature
COMBINATIONComined with phenytoin and hepatitis B core
PHYSICAL CONDITIONRefractory Epilepsy
RESPONSEIt prolongs the circulation time of the drug and efficiently load large amount of drugs, and showed
RESULTIt efficiently target the brain tissue by 2.4 fold and increase the antiepileptic efficiency of phen
LABELNA
PMID32087458