Detailed description page of B3Pdb
This page provides detail information of Selected ID b3pdb_1209 |
Primary information | |
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B3PDB ID | b3pdb_1209 |
Peptide Name | Penetratin |
PEPTIDE SEQUENCE (1-letter) | RQIKIWFQNRRMKWKK |
PEPTIDE SEQUENCE (3-letter) | NA |
N-terminal modification | NA |
C-terminal modification | NA |
Chemical modification | NA |
Peptide Length | 16 |
Conformation | Linear |
Peptide Nature | NA |
Source/Origin of peptide | Chemically synthesized |
SMILES | NA |
Cell Line | NA |
In vitro CONCENTRATION | NA |
In vitro METHOD | NA |
In vitro RESULT | NA |
ANIMAL MODEL | Male Sprague-Dawley rats |
In vivo CONCENTRATION | 2.0 mM |
In vivo MODE OF DELIVERY | Intranasal |
In vivo METHOD | ELISA |
In vivo RESULT | L-penetratin increased the systemic absorption of leptin after intranasal administration. |
ACTION | The intranasal coadministration with L-penetratin could deliver leptin to the brain and in particula |
TRANSPORT TYPE | Permeability |
SUBCELLULAR LOCALISATION | Hypothalamus |
COMBINATION | Combined with leptin |
PHYSICAL CONDITION | Obesity |
RESPONSE | NA |
RESULT | The intranasal coadministration with L-penetratin has a potential to deliver leptin into the therape |
LABEL | NA |
PMID | 31926192 |