Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0065
Primary information
B3PDB IDb3pdb_0065
Peptide NameAng-2
PEPTIDE SEQUENCE (1-letter)CTFFYGGSRGKRNNFKTEE
PEPTIDE SEQUENCE (3-letter)CysThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGlu
N-terminal modificationNA
C-terminal modificationNA
Chemical modificationNA
Peptide Length19
ConformationLinear
Peptide NatureNA
Source/Origin of peptideChemically synthesized
SMILESN[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O
Cell LineNA
In vitro CONCENTRATIONNA
In vitro METHODNA
In vitro RESULTNA
ANIMAL MODELC57BL6 mice
In vivo CONCENTRATION1 mg/mL
In vivo MODE OF DELIVERYIntraperitoneal
In vivo METHODFluorescent microscopy
In vivo RESULTLocalization of the nanoparticle within the brain cells, highlighting in particular the neuron accum
ACTIONBrain-targeted PLGA nanoparticles were able to cross the BBB and accumulated in neuronal cells, thus
TRANSPORT TYPETranscytosis
SUBCELLULAR LOCALISATIONNA
COMBINATIONConjugated to poly(lactic-co-glycolic acid) (PLGA)
PHYSICAL CONDITIONNA
RESPONSENA
RESULTNA
LABELNA
PMID31963430