Detailed description page of B3Pdb
This page provides detail information of Selected ID b3pdb_0053 |
| Primary information | |
|---|---|
| B3PDB ID | b3pdb_0053 |
| Peptide Name | Phage clone 1.3 |
| PEPTIDE SEQUENCE (1-letter) | GLHTSATNLYLH |
| PEPTIDE SEQUENCE (3-letter) | GlyLeuHisThrSerAlaThrAsnLeuTyrLeuHis |
| N-terminal modification | NA |
| C-terminal modification | NA |
| Chemical modification | NA |
| Peptide Length | 12 |
| Conformation | Linear |
| Peptide Nature | Cationic |
| Source/Origin of peptide | Chemically synthesized |
| SMILES | NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)O |
| Cell Line | SH-SY5Y cells |
| In vitro CONCENTRATION | NA |
| In vitro METHOD | UHPLC-MS/MS |
| In vitro RESULT | The phage display adverses the BBB with the peptide. |
| ANIMAL MODEL | NA |
| In vivo CONCENTRATION | NA |
| In vivo MODE OF DELIVERY | NA |
| In vivo METHOD | NA |
| In vivo RESULT | NA |
| ACTION | Peptides bound specifically to primary endothelial cells and could traverse the BBB. |
| TRANSPORT TYPE | Transcytosis |
| SUBCELLULAR LOCALISATION | NA |
| COMBINATION | Combined with phage display |
| PHYSICAL CONDITION | NA |
| RESPONSE | Stability/half life |
| RESULT | 3.3 x 10e-7 cm/s |
| LABEL | NA |
| PMID | 32079185 |