Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0052
Primary information
B3PDB IDb3pdb_0052
Peptide NamePhage clone 1.2
PEPTIDE SEQUENCE (1-letter)VAARTGEIYVPW
PEPTIDE SEQUENCE (3-letter)ValAlaAlaArgThrGlyGluIleTyrValProTrp
N-terminal modificationNA
C-terminal modificationNA
Chemical modificationNA
Peptide Length12
ConformationLinear
Peptide NatureCationic
Source/Origin of peptideChemically synthesized
SMILESN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)O
Cell LineSH-SY5Y cells
In vitro CONCENTRATIONNA
In vitro METHODUHPLC-MS/MS
In vitro RESULTThe phage display adverses the BBB with the peptide.
ANIMAL MODELNA
In vivo CONCENTRATIONNA
In vivo MODE OF DELIVERYNA
In vivo METHODNA
In vivo RESULTNA
ACTIONPeptides bound specifically to primary endothelial cells and could traverse the BBB.
TRANSPORT TYPETranscytosis
SUBCELLULAR LOCALISATIONNA
COMBINATIONCombined with phage display
PHYSICAL CONDITIONNA
RESPONSEStability/half life
RESULT1.5 x 10e-6 cm/s
LABELNA
PMID32079185