Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0051
Primary information
B3PDB IDb3pdb_0051
Peptide NameSLS
PEPTIDE SEQUENCE (1-letter)SLSHSPQ
PEPTIDE SEQUENCE (3-letter)SerLeuSerHisSerProGln
N-terminal modificationNA
C-terminal modificationNA
Chemical modificationNA
Peptide Length7
ConformationCyclic
Peptide NatureNeutral
Source/Origin of peptideChemically synthesized
SMILESN[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O
Cell LinehCMEC/D3 cell monolayers
In vitro CONCENTRATION200000 cells per well
In vitro METHODConfocal microscopy
In vitro RESULTIt promoted phage permeation across the hCMEC/D3 cell monolayer.
ANIMAL MODELMice
In vivo CONCENTRATIONNA
In vivo MODE OF DELIVERYIntravenous
In vivo METHODPlaque formation assay
In vivo RESULTCyclic SLS peptide facilitated phage permeation across the mouse BBB in vivo
ACTIONBBB-permeable cyclic SLS heptapeptide for brain delivery of macromolecules via macropinocytosis and
TRANSPORT TYPEMacropinocytosis
SUBCELLULAR LOCALISATIONBrain parenchyma
COMBINATIONCombined with M13 phage
PHYSICAL CONDITIONNA
RESPONSENA
RESULTNA
LABELNA
PMID32135226