Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0049
Primary information
B3PDB IDb3pdb_0049
Peptide NamegH625Cys
PEPTIDE SEQUENCE (1-letter)HGLASTLTRWAHYNALIRAF
PEPTIDE SEQUENCE (3-letter)HisGlyLeuAlaSerThrLeuThrArgTrpAlaHisTyrAsnAlaLeuIleArgAlaPhe
N-terminal modificationAcetylaed at N-terminal
C-terminal modificationCys-CONH2 group is attached at C-terminal
Chemical modificationNA
Peptide Length21
ConformationLinear
Peptide NatureNA
Source/Origin of peptideChemically synthesized
SMILESN[C@@]([H])(CC1=CN=C-N1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O
Cell LineBMECs
In vitro CONCENTRATION5 micromolar
In vitro METHODFluorescence microscopy
In vitro RESULTLiposomes preparations were non-toxic for the endothelial cells and improves the transfer of liposom
ANIMAL MODELMouse
In vivo CONCENTRATIONNA
In vivo MODE OF DELIVERYIntravenous
In vivo METHODFluorescence microscopy
In vivo RESULTgH625 ameliorates the efficiency of liposomes to deliver. PACAP
ACTIONgH625-liposomes represent a promising strategy to deliver therapeutic agents to CNS and to provide a
TRANSPORT TYPENA
SUBCELLULAR LOCALISATIONNA
COMBINATIONComined with liposome
PHYSICAL CONDITIONNA
RESPONSENA
RESULTNA
LABELNA
PMID31235716