Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0047
Primary information
B3PDB IDb3pdb_0047
Peptide NameC-TN-APNPs
PEPTIDE SEQUENCE (1-letter)CAQK
PEPTIDE SEQUENCE (3-letter)CysAlaGlnLys
N-terminal modificationNA
C-terminal modificationNA
Chemical modificationNA
Peptide Length4
ConformationLinear
Peptide NatureNA
Source/Origin of peptideChemically synthesized
SMILESN[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O
Cell LinehCMEC/D3 and NHA cells
In vitro CONCENTRATIONNA
In vitro METHODTEM imaging
In vitro RESULTResponsive to thrombin cleavage, reduced the cytotoxicity of Tat-NR2B9c, and increased BBB permeabil
ANIMAL MODELC57BL6 mice
In vivo CONCENTRATIONNA
In vivo MODE OF DELIVERYIntravenous
In vivo METHODDynamic light scattering
In vivo RESULTBetter circulation time, better targeting ability and penetrating efficiency to the injured brain, a
ACTIONTreatment reduced the injury size
TRANSPORT TYPENA
SUBCELLULAR LOCALISATIONNA
COMBINATIONCombined with Tat-NR2B9c
PHYSICAL CONDITIONTraumatic brain injury
RESPONSENA
RESULTNA
LABELNA
PMID31213815