Detailed description page of B3Pdb
This page provides detail information of Selected ID b3pdb_0045 |
| Primary information | |
|---|---|
| B3PDB ID | b3pdb_0045 |
| Peptide Name | MVIIA-c |
| PEPTIDE SEQUENCE (1-letter) | CKGKGAKCSRLMYDCCTGSCRSGKCGGYGRKKRRQRRR |
| PEPTIDE SEQUENCE (3-letter) | CysLysGlyLysGlyAlaLysCysSerArgLeuMetTyrAspCysCysThrGlySerCysArgSerGlyLysCysGlyGlyTyrGlyArgLysLysArgArgGlnArgArgArg |
| N-terminal modification | NA |
| C-terminal modification | TAT-transducing domain was fused at C-terminal |
| Chemical modification | NA |
| Peptide Length | 38 |
| Conformation | Linear |
| Peptide Nature | Cationic |
| Source/Origin of peptide | NA |
| SMILES | N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O |
| Cell Line | HEK293 cells |
| In vitro CONCENTRATION | NA |
| In vitro METHOD | Acetic Acid-Induced WRITHING test |
| In vitro RESULT | Inhibitory activity toward N-type calcium channels, albeit with a slightly reduced endothelialcacy i |
| ANIMAL MODEL | Kunming mice |
| In vivo CONCENTRATION | NA |
| In vivo MODE OF DELIVERY | Intranasal and Intervenous |
| In vivo METHOD | Tremor Symptom Test |
| In vivo RESULT | Ii did not induce tremor symptoms. |
| ACTION | It showed that C-terminal fusion with TAT peptide render its BBB penetration capacity, without signi |
| TRANSPORT TYPE | Receptor-mediated transcytosis |
| SUBCELLULAR LOCALISATION | NA |
| COMBINATION | Combined with TAT protein |
| PHYSICAL CONDITION | NA |
| RESPONSE | MIC |
| RESULT | 0.237 micromolar |
| LABEL | NA |
| PMID | 31083641 |