Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0044
Primary information
B3PDB IDb3pdb_0044
Peptide NameMVIIA-b
PEPTIDE SEQUENCE (1-letter)CKGKGAKCSRLMYDCCTGSCRSGKCGYGRKKRRQRRR
PEPTIDE SEQUENCE (3-letter)CysLysGlyLysGlyAlaLysCysSerArgLeuMetTyrAspCysCysThrGlySerCysArgSerGlyLysCysGlyTyrGlyArgLysLysArgArgGlnArgArgArg
N-terminal modificationNA
C-terminal modificationTAT-transducing domain was fused at C-terminal
Chemical modificationNA
Peptide Length37
ConformationLinear
Peptide NatureCationic
Source/Origin of peptideNA
SMILESN[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
Cell LineHEK293 cells
In vitro CONCENTRATIONNA
In vitro METHODAcetic Acid-Induced WRITHING test
In vitro RESULTInhibitory activity toward N-type calcium channels, albeit with a slightly reduced endothelialcacy i
ANIMAL MODELKunming mice
In vivo CONCENTRATIONNA
In vivo MODE OF DELIVERYIntranasal and Intervenous
In vivo METHODTremor Symptom Test
In vivo RESULTIt induces tremor symptoms
ACTIONIt showed that C-terminal fusion with TAT peptide render its BBB penetration capacity, without signi
TRANSPORT TYPEReceptor-mediated transcytosis
SUBCELLULAR LOCALISATIONNA
COMBINATIONCombined with TAT protein
PHYSICAL CONDITIONNA
RESPONSEMIC
RESULT0.379 micromolar
LABELNA
PMID31083641