Detailed description page of B3Pdb
This page provides detail information of Selected ID b3pdb_0038 |
| Primary information | |
|---|---|
| B3PDB ID | b3pdb_0038 |
| Peptide Name | ApoB11 |
| PEPTIDE SEQUENCE (1-letter) | RLTRKRGLKLA |
| PEPTIDE SEQUENCE (3-letter) | ArgLeuThrArgLysArgGlyLeuLysLeuAla |
| N-terminal modification | NA |
| C-terminal modification | 5 Gly (G) and 9 Arg (R) amino acids to the C-termi |
| Chemical modification | Coupled with a 9-amiNA acid arginine linker |
| Peptide Length | 11 |
| Conformation | NA |
| Peptide Nature | NA |
| Source/Origin of peptide | ApoB38 peptide |
| SMILES | N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)O |
| Cell Line | Mouse cholinergic cell line Neuro2A (N2A) |
| In vitro CONCENTRATION | 100000 cells/well |
| In vitro METHOD | Laser scanning confocal microscopy |
| In vitro RESULT | It crosses the BBB with conguagted siRNA for alpha-syn. |
| ANIMAL MODEL | Transgenic Mice |
| In vivo CONCENTRATION | 50 microgram |
| In vivo MODE OF DELIVERY | Intraperitoneal |
| In vivo METHOD | Laser scanning confocal microscopy |
| In vivo RESULT | It can transport siα-syn across the BBB as a therapeutic option for synucleinopathies. |
| ACTION | It showed reduced accumulation of α-syn associated with amelioration of the neurodegenerative and i |
| TRANSPORT TYPE | NA |
| SUBCELLULAR LOCALISATION | Neurons and glial cellsexhibiting α-syn accumulation |
| COMBINATION | Combined with siRNA for alpha-syn |
| PHYSICAL CONDITION | Lewy body disease |
| RESPONSE | NA |
| RESULT | NA |
| LABEL | NA |
| PMID | 30849508 |