Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0022
Primary information
B3PDB IDb3pdb_0022
Peptide NameTransportan 10
PEPTIDE SEQUENCE (1-letter)AGYLLGKINLKALAALAKKIL
PEPTIDE SEQUENCE (3-letter)AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal modificationN-terminal Fmoc group was removed and the propiola
C-terminal modificationAmide group is attached
Chemical modificationNA
Peptide Length21
ConformationLinear
Peptide NatureCationic
Source/Origin of peptideChemically synthesized
SMILESN[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Cell LineS. aureus MRSA hetero-VISA 6347b
In vitro CONCENTRATION100000 CFU/mL
In vitro METHODNA
In vitro RESULTNA
ANIMAL MODELBALB/c mice
In vivo CONCENTRATION60 mg/kg
In vivo MODE OF DELIVERYIntravenous
In vivo METHODFluorescence microscopy assay
In vivo RESULTIt crosses the BBB.
ACTIONIt shows intermediate susceptibility.
TRANSPORT TYPENA
SUBCELLULAR LOCALISATIONNA
COMBINATIONCombined with Vanomycin
PHYSICAL CONDITIONNA
RESPONSEMIC
RESULT3.1 ± 0.8 micromolar
LABELNA
PMID30824786