Detailed description page of B3Pdb
This page provides detail information of Selected ID b3pdb_0002 |
Primary information | |
---|---|
B3PDB ID | b3pdb_0002 |
Peptide Name | Tf-PFV |
PEPTIDE SEQUENCE (1-letter) | PFVYLI |
PEPTIDE SEQUENCE (3-letter) | ProPheValTyrLeuIle |
N-terminal modification | NA |
C-terminal modification | NA |
Chemical modification | NA |
Peptide Length | 6 |
Conformation | Linear |
Peptide Nature | Cationic |
Source/Origin of peptide | Chemically synthesized |
SMILES | N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O |
Cell Line | Glioblastoma (U87), brain endothelial (bEnd.3), an |
In vitro CONCENTRATION | NA |
In vitro METHOD | By measuring the flux of sodium fluorescence (Na-F) and TEER |
In vitro RESULT | The transport of Tf-PFV liposomes across the endothelial barrier layer into tumor grown in the porou |
ANIMAL MODEL | In vitro brain model |
In vivo CONCENTRATION | NA |
In vivo MODE OF DELIVERY | NA |
In vivo METHOD | NA |
In vivo RESULT | NA |
ACTION | The dual functionalized liposomes showed significantly higher cellular uptake as well as increased t |
TRANSPORT TYPE | Transcytosis |
SUBCELLULAR LOCALISATION | NA |
COMBINATION | Combination with the transferrin protein |
PHYSICAL CONDITION | Glioblastoma multiforme |
RESPONSE | NA |
RESULT | NA |
LABEL | NA |
PMID | 30261346 |