Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0002
Primary information
B3PDB IDb3pdb_0002
Peptide NameTf-PFV
PEPTIDE SEQUENCE (1-letter)PFVYLI
PEPTIDE SEQUENCE (3-letter)ProPheValTyrLeuIle
N-terminal modificationNA
C-terminal modificationNA
Chemical modificationNA
Peptide Length6
ConformationLinear
Peptide NatureCationic
Source/Origin of peptideChemically synthesized
SMILESN1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O
Cell LineGlioblastoma (U87), brain endothelial (bEnd.3), an
In vitro CONCENTRATIONNA
In vitro METHODBy measuring the flux of sodium fluorescence (Na-F) and TEER
In vitro RESULTThe transport of Tf-PFV liposomes across the endothelial barrier layer into tumor grown in the porou
ANIMAL MODELIn vitro brain model
In vivo CONCENTRATIONNA
In vivo MODE OF DELIVERYNA
In vivo METHODNA
In vivo RESULTNA
ACTIONThe dual functionalized liposomes showed significantly higher cellular uptake as well as increased t
TRANSPORT TYPETranscytosis
SUBCELLULAR LOCALISATIONNA
COMBINATIONCombination with the transferrin protein
PHYSICAL CONDITIONGlioblastoma multiforme
RESPONSENA
RESULTNA
LABELNA
PMID30261346