Detailed description page of B3Pdb


This page provides detail information of Selected ID b3pdb_0001
Primary information
B3PDB IDb3pdb_0001
Peptide NameMtfpep
PEPTIDE SEQUENCE (1-letter)DSSHAFTLDELR
PEPTIDE SEQUENCE (3-letter)AspSerSerHisAlaPheThrLeuAspGluLeuArg
N-terminal modificationNA
C-terminal modificationPolyethylene glycol (PEG)4 linker
Chemical modificationNA
Peptide Length12
ConformationLinear
Peptide NatureNA
Source/Origin of peptideMelanotransferrin
SMILESN[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
Cell LineNA
In vitro CONCENTRATIONNA
In vitro METHODNA
In vitro RESULTNA
ANIMAL MODELMice
In vivo CONCENTRATION2 MTfpep per NIP228 antibody
In vivo MODE OF DELIVERYIntravenous
In vivo METHOD3D confocal fluorescence microscopy
In vivo RESULTTwo times greater fractional fluorescence was measured in the brain parenchyma.
ACTIONIt delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates
TRANSPORT TYPETranscytosis
SUBCELLULAR LOCALISATIONSurface of normal brain endothelial cells, the main constituent of the BBB, and is able to cross thr
COMBINATIONSuccessfully delivers therapeutic amounts of an an
PHYSICAL CONDITIONNeuropathic pain
RESPONSEStability/half life
RESULT5.5 days
LABELNA
PMID29845881