Browse result page of B3Pdb

The total number entries retrieved from this search are 137, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0812Apidaecin Api137Guan-ONNRPVYIPRPRPPHPRLGuan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-LeuNANANA18LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 77% Direct iodination 24164260
b3pdb_0813Apidaecin Api137Guan-ONNRPVYIPRPRPPHPRLGuan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-LeuNANANA18LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.00073 mL/(g x min) Direct iodination 24164260
b3pdb_0814Apidaecin Api137Guan-ONNRPVYIPRPRPPHPRLGuan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-LeuNANANA18LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Initial disrobution volume 0.02343 ml/g Direct iodination 24164260
b3pdb_0873Dalargin-SS-SynB1YaGFLR-NHC2H4S-SC2H4NH-RGGRLSYSRRRFSTSTGR-NH2Tyr-(D)Ala-Gly-Phe-Leu-Arg-NHC2H4S-SC2H4NH-Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Arg-Arg-Arg-Phe-Ser-Thr-Ser-Thr-Gly-Arg-NH2NANACys-Cys (linker)20LinearNAChemically synthesizedNANANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Volume of donor compartment 0.309 ml/g H3/C14 12682214
b3pdb_0874Dalargin-SS-SynB3YaGFLR-C2H4S-SC2H4-RRLSYSRRRF-NH2Tyr-(D)Ala-Gly-Phe-Leu-Arg-NHC2H4S-SC2H4NH-Arg-Arg-Leu-Ser-Tyr-Ser-Arg-Arg-Arg-Phe-NH2NANACys-Cys (linker)16LinearNAChemically synthesizedNANANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Volume of donor compartment 0.24 ml/g H3/C14 12682214
b3pdb_0881Angiopep-1TFFYGGCRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Cys-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 37.28% Direct iodination 18156463
b3pdb_0882Angiopep-1TFFYGGCRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Cys-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 62.72% Direct iodination 18156463
b3pdb_0883Angiopep-1TFFYGGCRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Cys-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(brain/perfusate) 0.3537 ml/g Direct iodination 18156463
b3pdb_0884Angiopep-1TFFYGGCRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Cys-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(capillary/perfusate) 0.1341 ml/g Direct iodination 18156463
b3pdb_0885Angiopep-1TFFYGGCRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Cys-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(parenchyma/perfusate) 0.2256 ml/g Direct iodination 18156463
b3pdb_0886Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA saturable NA NA NA % capillary 15.47% Direct iodination 18156463
b3pdb_0887Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA saturable NA NA NA % parenchyma 84.53% Direct iodination 18156463
b3pdb_0888Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA saturable NA NA NA % parenchyma 84% Direct iodination 19818094
b3pdb_0889Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA saturable NA NA NA % capillary 15.63% Direct iodination 18489712
b3pdb_0890Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA saturable NA NA NA % parenchyma 84.37% Direct iodination 18489712
b3pdb_0891Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA saturable NA NA NA % capillary 16% Direct iodination 19818094
b3pdb_0892Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(capillary/perfusate) 0.04 ml/g Direct iodination 19818094
b3pdb_0893Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(brain/perfusate) 0.24 ml/g Direct iodination 19818094
b3pdb_0894Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(parenchyma/perfusate) 0.1976 ml/g Direct iodination 18489712
b3pdb_0895Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(brain/perfusate) 0.2342 ml/g Direct iodination 18489712
b3pdb_0896Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(parenchyma/perfusate) 0.2 ml/g Direct iodination 18156463
b3pdb_0897Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(capillary/perfusate) 0.0366 ml/g Direct iodination 18156463, 18489712
b3pdb_0898Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(brain/perfusate) 0.2317 ml/g Direct iodination 18156463
b3pdb_0899Angiopep-2TFFYGGSRGKRNNFKTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA CD(parenchyma/perfusate) 0.2 ml/g Direct iodination 19818094
b3pdb_0900Angiopep-5TFFYGGSRGKRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 9.53% Direct iodination 18156463
b3pdb_0901Angiopep-5TFFYGGSRGKRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 90.47% Direct iodination 18156463
b3pdb_0902Angiopep-5TFFYGGSRGKRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(brain/perfusate) 0.1341 ml/g Direct iodination 18156463
b3pdb_0903Angiopep-5TFFYGGSRGKRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(capillary/perfusate) 0.0122 ml/g Direct iodination 18156463
b3pdb_0904Angiopep-5TFFYGGSRGKRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(parenchyma/perfusate) 0.1158 ml/g Direct iodination 18156463
b3pdb_0905Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNA19LinearNAChemically synthesizedNANANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA % injected dose 0.22 %/g Direct iodination 29090274
b3pdb_0906Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 55% Direct iodination 19818094
b3pdb_0907Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 45% Direct iodination 19818094
b3pdb_0908Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 66.67% Direct iodination 18156463
b3pdb_0909Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 33.33% Direct iodination 18156463
b3pdb_0910Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(parenchyma/perfusate) 0.0366 ml/g Direct iodination 19818094
b3pdb_0911Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(capillary/perfusate) 0.0183 ml/g Direct iodination 18156463
b3pdb_0912Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(brain/perfusate) 0.061 ml/g Direct iodination 18156463
b3pdb_0913Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(brain/perfusate) 0.054 ml/g Direct iodination 19818094
b3pdb_0914Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(capillary/perfusate) 0.024 ml/g Direct iodination 19818094
b3pdb_0915Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNANANA19LinearNAChemically synthesizedNANANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(parenchyma/perfusate) 0.03 ml/g Direct iodination 18489712
b3pdb_0916Angiopep-7TFFYGGSRGRRNNFRTEEYThr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-TyrNA19LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA NA NA NA NA % injected dose 0.032 %/g Direct iodination 29090274
b3pdb_0917Exendin-4-NH2HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2NANANA19LinearNAChemically synthesizedCCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O) NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC (CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(= O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C) C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C (CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC (=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)NNANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 20.22% Direct iodination 18489712
b3pdb_0918Exendin-4-NH2HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2NANANA19LinearNAChemically synthesizedCCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O) NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC (CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(= O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C) C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C (CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC (=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)NNANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 79.78% Direct iodination 18489712
b3pdb_0919Exendin-4-NH2HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2NANANA19LinearNAChemically synthesizedCCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O) NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC (CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(= O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C) C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C (CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC (=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)NNANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(brain/perfusate) 0.0183 ml/g Direct iodination 18489712
b3pdb_0920Exendin-4-NH2HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2NANANA19LinearNAChemically synthesizedCCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O) NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC (CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(= O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C) C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C (CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC (=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)NNANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(parenchyma/perfusate) 0.0146 ml/g Direct iodination 18489712
b3pdb_0921Exendin-4-NH2HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2NANANA19LinearNAChemically synthesizedCCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O) NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC (CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(= O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C) C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C (CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC (=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)NNANACapillary deplition in situ b pNANANANANANA NA NA NA NA NA CD(capillary/perfusate) 0.0037 ml/g Direct iodination 18489712
b3pdb_0922OncocinVDKPPYLPRPRPPRRIYNR-NH2Val-Asp-Lys-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Arg-Arg-Ile-Tyr-Asn-Arg-NH2NANANA19LinearNAChemically synthesizedNANANAEfflux study ICUNANANANANANA NA Permeability NA NA NA Brain elemination rate constant 0.002 min-1 Direct iodination 24164260
b3pdb_0923OncocinVDKPPYLPRPRPPRRIYNR-NH2Val-Asp-Lys-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Arg-Arg-Ile-Tyr-Asn-Arg-NH2NANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 82% Direct iodination 24164260
b3pdb_0924OncocinVDKPPYLPRPRPPRRIYNR-NH2Val-Asp-Lys-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Arg-Arg-Ile-Tyr-Asn-Arg-NH2NANANA19LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 18% Direct iodination 24164260
b3pdb_0925OncocinVDKPPYLPRPRPPRRIYNR-NH2Val-Asp-Lys-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Arg-Arg-Ile-Tyr-Asn-Arg-NH2NANANA19LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.00044 mL/(g x min) Direct iodination 24164260