Browse result page of B3Pdb

The total number entries retrieved from this search are 53, scroll left/right for detailed information.
B3pdbIDb3pdb_0071PEPTIDE NAMEVasoactive IntestinaPEPTIDE SEQUENCE (1-letter)NAPEPTIDE SEQUENCE (3-letter)NAN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEporcine duodenum, CNS, Cerebrospinal FluidSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELMongrel dogs, 5 humanIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODportacaval shunt procedureIn vivo RESULTNA ACTIONDoes not cross the BBB. Represents a central nervous system response to the systemic metabolic event TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSENA RESULTNA LABELNAPMID 31806
B3pdbIDb3pdb_0258PEPTIDE NAMEVasoactive IntestinaPEPTIDE SEQUENCE (1-letter)NAPEPTIDE SEQUENCE (3-letter)NAN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONNAPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEporcine duodenum, CNS, Cerebrospinal FluidSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODMongrel dogs, 5 humanIn vitro RESULTNAANIMAL MODELportacaval shunt procedureIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONDoes not cross the BBB. Represents a central nervous system response to the systemic metabolic event TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSENA RESULTNA LABELNAPMID 31806
B3pdbIDb3pdb_0325PEPTIDE NAMERVGPEPTIDE SEQUENCE (1-letter)NAPEPTIDE SEQUENCE (3-letter)NAN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH29PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDENASMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSENA RESULTNA LABELNAPMID 27983648
B3pdbIDb3pdb_0425PEPTIDE NAMEPituitary adenylate PEPTIDE SEQUENCE (1-letter)HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2PEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,ratSMILESN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.00213 mL/(g x min) LABELDirect iodinationPMID 8246142
B3pdbIDb3pdb_0426PEPTIDE NAMEPituitary adenylate PEPTIDE SEQUENCE (1-letter)HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2PEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,ratSMILESN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial distribution volume RESULT0.0141 ml/g LABELDirect iodinationPMID 8246142
B3pdbIDb3pdb_0427PEPTIDE NAMEPituitary adenylate PEPTIDE SEQUENCE (1-letter)HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2PEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,ratSMILESN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODEfflux study ICUIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEsaturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEhalf life, brain RESULT11.8 min LABELDirect iodinationPMID 8246142
B3pdbIDb3pdb_0428PEPTIDE NAMEPituitary adenylate PEPTIDE SEQUENCE (1-letter)HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2PEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,ratSMILESN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODEfflux study ICUIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEsaturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEBrain elemination rate constant RESULT0.059 min-1 LABELDirect iodinationPMID 8246142
B3pdbIDb3pdb_0429PEPTIDE NAMEPituitary adenylate PEPTIDE SEQUENCE (1-letter)HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2PEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,ratSMILESN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT76.9 %/g LABELDirect iodinationPMID 8246142
B3pdbIDb3pdb_0430PEPTIDE NAMEPituitary adenylate PEPTIDE SEQUENCE (1-letter)HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2PEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,ratSMILESN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODShake FlaskIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSELog P RESULT-1.42 LABELDirect iodinationPMID 8246142
B3pdbIDb3pdb_0438PEPTIDE NAMEVasoactive intestinaPEPTIDE SEQUENCE (1-letter)HSDAVFTDNYTRLRKQMAVKKYLNSILNPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,rat,porcineSMILESCCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.0004 mL/(g x min) LABELDirect iodinationPMID 12732342
B3pdbIDb3pdb_0439PEPTIDE NAMEVasoactive intestinaPEPTIDE SEQUENCE (1-letter)HSDAVFTDNYTRLRKQMAVKKYLNSILNPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,rat,porcineSMILESCCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial distribution volume RESULT0.00028 ml/g LABELDirect iodinationPMID 12732342
B3pdbIDb3pdb_0440PEPTIDE NAMEVasoactive intestinaPEPTIDE SEQUENCE (1-letter)HSDAVFTDNYTRLRKQMAVKKYLNSILNPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,rat,porcineSMILESCCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYin situ brain perfusionIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional flux rate constant RESULT0.00216 mL/(g x min) LABELDirect iodinationPMID 12732342
B3pdbIDb3pdb_0441PEPTIDE NAMEVasoactive intestinaPEPTIDE SEQUENCE (1-letter)HSDAVFTDNYTRLRKQMAVKKYLNSILNPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,rat,porcineSMILESCCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT86.6 %/g LABELDirect iodinationPMID 12732342
B3pdbIDb3pdb_0442PEPTIDE NAMEVasoactive intestinaPEPTIDE SEQUENCE (1-letter)HSDAVFTDNYTRLRKQMAVKKYLNSILNPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,rat,porcineSMILESCCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT69.8 %/g LABELDirect iodinationPMID 12732342
B3pdbIDb3pdb_0443PEPTIDE NAMEVasoactive intestinaPEPTIDE SEQUENCE (1-letter)HSDAVFTDNYTRLRKQMAVKKYLNSILNPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,rat,porcineSMILESCCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT72.2 %/g LABELDirect iodinationPMID 12732342
B3pdbIDb3pdb_0444PEPTIDE NAMEVasoactive intestinaPEPTIDE SEQUENCE (1-letter)HSDAVFTDNYTRLRKQMAVKKYLNSILNPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,bovine,mouse,rat,porcineSMILESCCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODShake FlaskIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSELog P RESULT-2.19 LABELDirect iodinationPMID 12732342
B3pdbIDb3pdb_0454PEPTIDE NAMEOrexin BPEPTIDE SEQUENCE (1-letter)RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2PEPTIDE SEQUENCE (3-letter)Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,pig,mouse,rat,porcineSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEhalf life, serum RESULT4.4 min LABELDirect iodinationPMID 10087007
B3pdbIDb3pdb_0455PEPTIDE NAMEOrexin BPEPTIDE SEQUENCE (1-letter)RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2PEPTIDE SEQUENCE (3-letter)Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2N-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,pig,mouse,rat,porcineSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODShake FlaskIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSELog P RESULT-1.52 LABELDirect iodinationPMID 10087007
B3pdbIDb3pdb_0500PEPTIDE NAMEGhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQRVQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEhuman,ratSMILESCCCCCCCC(=O)OCC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)N2CCCC2C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC=N3)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)N6CCCC6C(=O)NC(CCCNC(=N)N)C(=O)O)NC(=O)C(CO)NC(=O)CNCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSENA RESULTNA LABELNAPMID NA
B3pdbIDb3pdb_0511PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.000954 mL/(g x min) LABELDirect iodinationPMID 9663454
B3pdbIDb3pdb_0512PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial distribution volume RESULT0.0099 ml/g LABELDirect iodinationPMID 9663454
B3pdbIDb3pdb_0513PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT0.12 %/g LABELDirect iodinationPMID 9663454
B3pdbIDb3pdb_0514PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.000899 mL/(g x min) LABELDirect iodinationPMID 7475950
B3pdbIDb3pdb_0515PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial distribution volume RESULT0.0121 ml/g LABELDirect iodinationPMID 7475950
B3pdbIDb3pdb_0516PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODCapillary depletionIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% capillary RESULT2% LABELDirect iodinationPMID 7475950
B3pdbIDb3pdb_0517PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODCapillary depletionIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% parenchyma RESULT98% LABELDirect iodinationPMID 7475950
B3pdbIDb3pdb_0518PEPTIDE NAME[Tyr10] Secretin-27PEPTIDE SEQUENCE (1-letter)HSDGTFTSEYSRLRDSARLQRLLQGLVPEPTIDE SEQUENCE (3-letter)His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-ValN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEGila monsterSMILES[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODShake FlaskIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSELog P RESULT-2.76 LABELDirect iodinationPMID 7475950
B3pdbIDb3pdb_0658PEPTIDE NAMEDes-octanoyl ghrelinPEPTIDE SEQUENCE (1-letter)GSSFLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYin situ brain perfusionIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional flux rate constant RESULT0.000573 mL/(g x min) LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0659PEPTIDE NAMEDes-octanoyl ghrelinPEPTIDE SEQUENCE (1-letter)GSSFLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYin situ brain perfusionIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial distribution vaolume RESULT0.011 ml/g LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0660PEPTIDE NAMEDes-octanoyl ghrelinPEPTIDE SEQUENCE (1-letter)GSSFLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT0.02 %/g LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0661PEPTIDE NAMEDes-octanoyl ghrelinPEPTIDE SEQUENCE (1-letter)GSSFLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODShake FlaskIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSELog P RESULT-1.95 LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0662PEPTIDE NAMEDes-octanoyl ghrelinPEPTIDE SEQUENCE (1-letter)GSSFLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.0007944 mL/(g x min) LABELDirect iodinationPMID 30293893
B3pdbIDb3pdb_0663PEPTIDE NAMEDes-octanoyl ghrelinPEPTIDE SEQUENCE (1-letter)GSSFLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial disrobution volume RESULT0.001775 ml/g LABELDirect iodinationPMID 30293893
B3pdbIDb3pdb_0815PEPTIDE NAMEnon-cyclic AmylinPEPTIDE SEQUENCE (1-letter)KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYPEPTIDE SEQUENCE (3-letter)Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-TyrN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEsynthetic,honey beeSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODCapillary depletionIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% capillary RESULT23% LABELDirect iodinationPMID 24164260
B3pdbIDb3pdb_0957PEPTIDE NAMEmouse GhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODEfflux study ICUIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEsaturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEhalf life, brain RESULT16.4 min LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0958PEPTIDE NAMEmouse GhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODEfflux study ICUIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEsaturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEBrain elemination rate constant RESULT0.042 min-1 LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0959PEPTIDE NAMEmouse GhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT0.01 %/g LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0960PEPTIDE NAMEmouse GhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODHPLCIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSE% injected dose RESULT0.005 %/g LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0961PEPTIDE NAMEmouse GhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODShake FlaskIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSELog P RESULT-1.24 LABELDirect iodinationPMID 12130749
B3pdbIDb3pdb_0962PEPTIDE NAMEmouse GhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.0001852 mL/(g x min) LABELDirect iodinationPMID 30293893
B3pdbIDb3pdb_0963PEPTIDE NAMEmouse GhrelinPEPTIDE SEQUENCE (1-letter)GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPRPEPTIDE SEQUENCE (3-letter)Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-ArgN-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial disrobution volume RESULT0.002847 ml/g LABELDirect iodinationPMID 30293893
B3pdbIDb3pdb_1039PEPTIDE NAMEβ-Amyloid1-28PEPTIDE SEQUENCE (1-letter)DAEFRHDSGYQVHHQKLVFFAEDVGSNKPEPTIDE SEQUENCE (3-letter)Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-LysN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDENASMILESN[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODEfflux study ICUIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEhalf life, brain RESULT20.6 min LABELDirect iodinationPMID 1786560
B3pdbIDb3pdb_1040PEPTIDE NAMEβ-Amyloid1-28PEPTIDE SEQUENCE (1-letter)DAEFRHDSGYQVHHQKLVFFAEDVGSNKPEPTIDE SEQUENCE (3-letter)Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-LysN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDENASMILESN[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODEfflux study ICUIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEBrain elemination rate constant RESULT0.015 min-1 LABELDirect iodinationPMID 1786560
B3pdbIDb3pdb_1041PEPTIDE NAMEβ-Amyloid1-28PEPTIDE SEQUENCE (1-letter)DAEFRHDSGYQVHHQKLVFFAEDVGSNKPEPTIDE SEQUENCE (3-letter)Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-LysN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDENASMILESN[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODShake FlaskIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSELog P RESULT-1.53 LABELDirect iodinationPMID 1786560
B3pdbIDb3pdb_1042PEPTIDE NAMEβ-Amyloid1-28PEPTIDE SEQUENCE (1-letter)DAEFRHDSGYQVHHQKLVFFAEDVGSNKPEPTIDE SEQUENCE (3-letter)Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-LysN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDENASMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODCapillary deplition in situ b pIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPENA SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectonal influx rate constant RESULT0.00098 mL/(g x min) LABELDirect iodinationPMID 8280117
B3pdbIDb3pdb_1043PEPTIDE NAMEβ-Amyloid1-28PEPTIDE SEQUENCE (1-letter)DAEFRHDSGYQVHHQKLVFFAEDVGSNKPEPTIDE SEQUENCE (3-letter)Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-LysN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDENASMILESN[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.000386 mL/(g x min) LABELDirect iodinationPMID 1786560
B3pdbIDb3pdb_1044PEPTIDE NAMEβ-Amyloid1-28PEPTIDE SEQUENCE (1-letter)DAEFRHDSGYQVHHQKLVFFAEDVGSNKPEPTIDE SEQUENCE (3-letter)Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-LysN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH28PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDENASMILESN[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)OCELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEnon saturable SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEInitial disrobution volume RESULT0.0159 ml/g LABELDirect iodinationPMID 1786560
B3pdbIDb3pdb_1093PEPTIDE NAMESNX-231PEPTIDE SEQUENCE (1-letter)CKGKGA-Hyp-CRKTMYDCCSGSCGRRGKCPEPTIDE SEQUENCE (3-letter)Cys-Lys-Gly-Lys-Gly-Ala-Hyp-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-CysN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONCys1-Cys16; Cys8-Cys20; Cys15-Cys26PEPTIDE LENGTH26PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODBMECIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEPermeability coefficient RESULT0.00001317 cm/s LABELNAPMID 10822104
B3pdbIDb3pdb_1094PEPTIDE NAMESNX-185PEPTIDE SEQUENCE (1-letter)CLS-Hyp-GSSCS-Hyp-TSYNCCRSCN-Hyp-YSRKCRPEPTIDE SEQUENCE (3-letter)Cys-Leu-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Ser-Arg-Lys-Cys-ArgN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONCys1-Cys16; Cys8-Cys20; Cys15-Cys26PEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODBMECIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYNAIn vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEPermeability coefficient RESULT0.0000145 cm/s LABELNAPMID 10822104
B3pdbIDb3pdb_1186PEPTIDE NAMEAH-DPEPTIDE SEQUENCE (1-letter)SGSWLRDVWDWICTVLTDFKTWLQSKLPEPTIDE SEQUENCE (3-letter)Ser-Gly-Ser-Trp-Leu-Arg-Asp-Val-Trp-Asp-Trp-Ile-Cys-Thr-Val-Leu-Thr-Asp-Phe-Lys-Thr-Trp-Leu-Gln-Ser-Lys-LeuN-TERMINAL MODIFICATIONNAC-TERMINAL MODIFICATION NACHEMICAL MODIFICATIONNAPEPTIDE LENGTH27PEPTIDE CONFORMATIONLinearPEPTIDE NATURENASOURCE/ORIGIN OF PEPTIDEChemically synthesizedSMILESNACELL LINENAIn vitro CONCENTRATIONNAIn vitro METHODNAIn vitro RESULTNAANIMAL MODELNAIn vivo CONCENTRATIONNAIn vivo MODE OF DELIVERYIntravenous In vivo METHODNAIn vivo RESULTNA ACTIONNA TRANSPORT TYPEPermeability SUBCELLULAR LOCALISATIONNA COMBINATIONNA PHYSICAL CONDITIONNA RESPONSEUnidirectional influx rate constant RESULT0.0003853 mL/(g x min) LABELNAPMID 30349030