Browse result page of B3Pdb

The total number entries retrieved from this search are 95, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0468Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.000052 mL/(g x min) Direct iodination 10617143
b3pdb_0469Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAIntravenous NANA NA Permeability NA NA NA Initial distribution volume 0.0153 ml/g Direct iodination 10617143
b3pdb_0470Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Initial distribution vaolume 0.00137 ml/g Direct iodination 10617143
b3pdb_0471Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Unidirectional flux rate constant 0.000594 mL/(g x min) Direct iodination 10617143
b3pdb_0472Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 20% Direct iodination 10617143
b3pdb_0473Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 80% Direct iodination 10617143
b3pdb_0474Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAHPLCNANANANANANA NA NA NA NA NA % injected dose 53.3 %/g Direct iodination 10617143
b3pdb_0475Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAHPLCNANANANANANA NA NA NA NA NA % injected dose 78.7 %/g Direct iodination 10617143
b3pdb_0476Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAHPLCNANANANANANA NA NA NA NA NA % injected dose 83.3 %/g Direct iodination 10617143
b3pdb_0477Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAShake FlaskNANANANANANA NA NA NA NA NA Log P -1.04 Direct iodination 10617143
b3pdb_0479Deltorphin II, [D-AlYaFEVVG-NH2Tyr-(D)Ala-Phe-Glu-Val-Val-Gly-NH2NA7LinearNAhuman,mouse,ratO=C(N)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C)Cc2ccccc2)CCC(=O)O)C(C)C)C(C)CNANABMECNANANABMECNANA NA (saturable) NA NA NA Permeability coefficient 0.00003915 cm/s NA 9152390
b3pdb_0519[Met5] EnkephalinYGGFMTyr-Gly-Gly-Phe-MetNANANA5LinearNAmouse,ratO=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CCSCNANANANANANAIntracarotid injectionNANA NA Permeability NA NA NA Blood/brain ratio 48 Direct iodination 2413968
b3pdb_0520[Met5] EnkephalinYGGFMTyr-Gly-Gly-Phe-MetNANANA5LinearNAmouse,ratO=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CCSCNANABMECNANANANANANA NA Permeability NA NA NA Permeability coefficient 0.00002 cm/s NA 9392847
b3pdb_0521[Met5] EnkephalinYGGFMTyr-Gly-Gly-Phe-MetNANANA5LinearNAmouse,ratO=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CCSCNANABMECNANANANANANA NA Permeability NA NA NA Permeability coefficient 0.0000774 cm/s NA 8371162, 8769896
b3pdb_0648Urocortin IIIFTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQIPhe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-IleNANANA38LinearNAmouseN[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)ONANANANANANAIntracarotid injectionNANA NA Permeability NA NA NA Blood/brain ratio 92 Direct iodination 2413968
b3pdb_0649Luteinizing hormone-Pyr-HWSYGLRPGPyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNANANA10LinearNAmouseO=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6NANAEfflux study ICUNANANANANANA NA Permeability NA NA NA half life, brain 15 min Direct iodination 1887877
b3pdb_0650Luteinizing hormone-Pyr-HWSYGLRPGPyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNANANA10LinearNAmouseO=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6NANAEfflux study ICUNANANANANANA NA Permeability NA NA NA Brain elemination rate constant 0.046 min-1 Direct iodination 1887877
b3pdb_0651Luteinizing hormone-Pyr-HWSYGLRPGPyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNANANA10LinearNAmouseO=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6NANANANANANAin situ brain perfusionNANA NA saturable NA NA NA Unidirectional flux rate constant 0.01251 mL/(g x min) Direct iodination 1887877
b3pdb_0652Luteinizing hormone-Pyr-HWSYGLRPGPyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNANANA10LinearNAmouseO=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6NANANANANANAin situ brain perfusionNANA NA saturable NA NA NA Permeability surface area cofficient 0.02 µL/(g x min) Direct iodination 1887877
b3pdb_0653Luteinizing hormone-Pyr-HWSYGLRPGPyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNANANA10LinearNAmouseO=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6NANAShake FlaskNANANANANANA NA NA NA NA NA Log P -1.43 Direct iodination 1887877
b3pdb_0654Luteinizing hormone-Pyr-HWSYGLRPGPyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNANANA10LinearNAmouseO=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6NANAShake FlaskNANANANANANA NA NA NA NA NA Log P -1.35 Direct iodination 1887877
b3pdb_0655Luteinizing hormone-Pyr-HWSYGLRPGPyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNANANA10LinearNAmouseO=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6NANANANANANAIntracarotid injectionNANA NA Permeability NA NA NA Blood/brain ratio 126 Direct iodination 2413968
b3pdb_06573,3-dimethylprolinamPyr-H-(3,3-Me)PPyr-His-(3,3-Me)ProNANANA3LinearNAhuman,mouse,rat,porcineO=C(N1[C@H](C(=O)O)C(C)(C)CC1)[C@H](NC(=O)[C@H]2NC(=O)CC2)Cc3ncnc3NANANANANANANANANA NA NA NA NA NA NA NA NA NA
b3pdb_0675α Melanocyte stimulaAc-SYSMEHFRWGKPVAc-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-ValNANANA13LinearNAmouse,ratO=C(N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CCC1)CCCCN)Cc3c2ccccc2nc3)CCCNC(=[N@H])N)Cc4ccccc4)Cc5ncnc5)CCC(=O)O)CCSC)CO)[C@@H](NC(=O)[C@H](NC(=O)C)CO)Cc6ccc(O)cc6NANANANANANAIntracarotid injectionNANA NA Permeability NA NA NA Blood/brain ratio 108 Direct iodination 2413968
b3pdb_0677JMV 2012KKPYILKKPYILLys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-LeuNANANA12LinearNAhuman,mouse,ratO=C(NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CC(C)C)C(C)CC)Cc2ccc(O)cc2)CCC3)CCCCN)CCCCN)CC(C)C)C(C)CC)Cc4ccc(O)cc4)CCCCN)C(N)CCCCNNANANANANANAin situ brain perfusionNANA NA saturable NA NA NA Unidirectional flux rate constant 0.00339 mL/(g x min) Direct iodination 8786534
b3pdb_0678JMV 2012KKPYILKKPYILLys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-LeuNANANA12LinearNAhuman,mouse,ratO=C(NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CC(C)C)C(C)CC)Cc2ccc(O)cc2)CCC3)CCCCN)CCCCN)CC(C)C)C(C)CC)Cc4ccc(O)cc4)CCCCN)C(N)CCCCNNANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Initial distribution vaolume 0.0267 ml/g Direct iodination 8786534
b3pdb_0679JMV 2012KKPYILKKPYILLys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-LeuNANANA12LinearNAhuman,mouse,ratO=C(NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CC(C)C)C(C)CC)Cc2ccc(O)cc2)CCC3)CCCCN)CCCCN)CC(C)C)C(C)CC)Cc4ccc(O)cc4)CCCCN)C(N)CCCCNNANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA permiability constant 0.000000565 cm/s Direct iodination 8786534
b3pdb_0680JMV 2012KKPYILKKPYILLys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-LeuNANANA12LinearNAhuman,mouse,ratO=C(NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CC(C)C)C(C)CC)Cc2ccc(O)cc2)CCC3)CCCCN)CCCCN)CC(C)C)C(C)CC)Cc4ccc(O)cc4)CCCCN)C(N)CCCCNNANABMECNANANANANANA NA saturable NA NA NA Permeability coefficient 0.000153333 cm/s NA 8371162, 8786534
b3pdb_0714NT27R-orn-PYILArg-(D)Orn-Pro-Tyr-Ile-LeuNANANA6LinearNAhuman,bovine,mouse,rat,guinea pigO=C(N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)O)CC(C)C)[C@H](C)CC)Cc1ccc(O)cc1)[C@H]2N(C(=O)[C@H](NC(=O)[C@@H](N)CCCNC(=[N@H])N)CCCN)CCC2NANANANANANANANANA NA NA NA NA NA NA NA NA NA
b3pdb_0784P42(Me2)Y-rF-Nle-NH2(Me2)Tyr-(D)Arg-Phe-Nle-NH2NANANA4LinearNAmouseO=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCCNANAEfflux study ICUNANANANANANA NA Permeability NA NA NA Brain elemination rate constant -0.039 min-1 Direct iodination 23102273
b3pdb_0785P42(Me2)Y-rF-Nle-NH2(Me2)Tyr-(D)Arg-Phe-Nle-NH2NANANA4LinearNAmouseO=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCCNANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 32.97% Direct iodination 23102273
b3pdb_0786P42(Me2)Y-rF-Nle-NH2(Me2)Tyr-(D)Arg-Phe-Nle-NH2NANANA4LinearNAmouseO=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCCNANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 67.03% Direct iodination 23102273
b3pdb_0787P42(Me2)Y-rF-Nle-NH2(Me2)Tyr-(D)Arg-Phe-Nle-NH2NANANA4LinearNAmouseO=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCCNANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant,initial 0.00848 ml/(g x min) Direct iodination 23102273
b3pdb_0788P42(Me2)Y-rF-Nle-NH2(Me2)Tyr-(D)Arg-Phe-Nle-NH2NANANA4LinearNAmouseO=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCCNANANANANANAIntravenous NANA NA Permeability NA NA NA Initial disrobution volume 0.02743 ml/g Direct iodination 23102273
b3pdb_0789P42(Me2)Y-rF-Nle-NH2(Me2)Tyr-(D)Arg-Phe-Nle-NH2NANANA4LinearNAmouseO=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCCNANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.0002485 mL/(g x min) Direct iodination _
b3pdb_0824RC-121fCYwKVCT-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Thr-NH2NANACys2-Cys78LinearNAmouse,ratO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)C(O)CNANAEfflux study ICUNANANANANANA NA Permeability NA NA NA half life, brain 14.4 min Direct iodination 1975697
b3pdb_0825RC-121fCYwKVCT-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Thr-NH2NANACys2-Cys78LinearNAmouse,ratO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)C(O)CNANAEfflux study ICUNANANANANANA NA Permeability NA NA NA Brain elemination rate constant 0.05 min-1 Direct iodination 1975697
b3pdb_0826RC-121fCYwKVCT-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Thr-NH2NANACys2-Cys78LinearNAmouse,ratO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)C(O)CNANANANANANAIntravenous NANA NA non saturable NA NA NA Unidirectional influx rate constant 0.0000401 mL/(g x min) Direct iodination 1975697
b3pdb_0827RC-121fCYwKVCT-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Thr-NH2NANACys2-Cys78LinearNAmouse,ratO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)C(O)CNANANANANANAIntravenous NANA NA Permeability NA NA NA Initial disrobution volume 0.0136 ml/g Direct iodination 1975697
b3pdb_0828RC-121fCYwKVCT-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Thr-NH2NANACys2-Cys78LinearNAmouse,ratO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)C(O)CNANANANANANAIntravenous NANA NA Permeability NA NA NA half life, serum 4.6 min Direct iodination 1975697
b3pdb_0967Benzylpenicillin-SynBenzylpenicillin-RGGRLSYSRRRFSTSTGRBenzylpenicillin-Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Arg-Arg-Arg-Phe-Ser-Thr-Ser-Thr-Gly-ArgNANANA18LinearNAmouseNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 20% H3/C14 12164379
b3pdb_0968Benzylpenicillin-SynBenzylpenicillin-RGGRLSYSRRRFSTSTGRBenzylpenicillin-Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Arg-Arg-Arg-Phe-Ser-Thr-Ser-Thr-Gly-ArgNANANA18LinearNAmouseNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 80% Direct iodination 12164379
b3pdb_1200tANK6RKRIRLVTKKKRRKRIRLVTKKKRArg-Lys-Arg-Ile-Arg-Leu-Val-Thr-Lys-Lys-Lys-Arg-Arg-Lys-Ile-Arg-Leu-Val-Thr-Lys-Lys-Lys-ArgNANANA24LinearNAmouseNANANANANANANAIntravenous NANA NA Permeability NA NA NA Peak response 1.6 µL/(g x min) H3/C14 29966196
b3pdb_1201tANK6RKRIRLVTKKKRRKRIRLVTKKKRArg-Lys-Arg-Ile-Arg-Leu-Val-Thr-Lys-Lys-Lys-Arg-Arg-Lys-Ile-Arg-Leu-Val-Thr-Lys-Lys-Lys-ArgNANANA24LinearNAmouseNANANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.0016 mL/(g x min) H3/C14 29966196
b3pdb_1202tANK6RKRIRLVTKKKRRKRIRLVTKKKRArg-Lys-Arg-Ile-Arg-Leu-Val-Thr-Lys-Lys-Lys-Arg-Arg-Lys-Ile-Arg-Leu-Val-Thr-Lys-Lys-Lys-ArgNANANA24LinearNAmouseNANANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.5833 ml/g H3/C14 29966196