Browse result page of AntiTbPdb
The total number entries retrieved from this search are 452
| ID | Name | Sequence | N-Terminal Modification | C-Terminal Modification | Chemical Modification | Linear/Cyclic | Length | Chirality | Nature | Source | Origin | Species | Strain | Inhibition Concentration | In vitro/ In vivo | Cell Line | Intracellular Inhibition | Cytotoxicity | Animal Model | Effective Dose in model organism | Immune Responce | Mechanism of Action | Target | Combination Therapy | Other Activities | Year of Publication | Pubmed ID/ Patent No. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| antitb_1616 | LK | LLKKLLKK | Free | Amidation | None | Linear | 8 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 125 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2015 | 26380930 |
| antitb_1617 | PP | PLLKKLLKKP | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 250 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2015 | 26380930 |
| antitb_1618 | CC | CLLKKLLKKC | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 250 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2015 | 26380930 |
| antitb_1619 | II | ILLKKLLKKI | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 62.5 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2015 | 26380930 |
| antitb_1620 | MM | MLLKKLLKKM | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 62.5 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2015 | 26380930 |
| antitb_1621 | WW | WLLKKLLKKW | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 62.5 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2015 | 26380930 |
| antitb_1622 | LK | LLKKLLKK | Free | Amidation | None | Linear | 8 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 62.5 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide + Rifampicin (0.98 μg/ml) | NA | 2015 | 26380930 |
| antitb_1623 | PP | PLLKKLLKKP | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 125 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide + Rifampicin (0.98 μg/ml) | NA | 2015 | 26380930 |
| antitb_1624 | CC | CLLKKLLKKC | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 250 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide + Rifampicin (0.98 μg/ml) | NA | 2015 | 26380930 |
| antitb_1625 | II | ILLKKLLKKI | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 15.6 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide + Rifampicin (0.98 μg/ml) | NA | 2015 | 26380930 |
| antitb_1626 | MM | MLLKKLLKKM | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 15.6 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | HC50= >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide + Rifampicin (0.98 μg/ml) | NA | 2015 | 26380930 |
| antitb_1627 | WW | WLLKKLLKKW | Free | Amidation | None | Linear | 10 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC14468 | MIC = 0.98 μg/ml | in vitro | RAW 264.7 mouse macrophage | NA | >500 μg/ml | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide + Rifampicin (0.98 μg/ml) | NA | 2015 | 26380930 |
| antitb_1628 | LL-37 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | Free | Free | None | Linear | 37 | L | Cationic | Synthetic | NA | Mycobacterium smegmatis | Mycobacteria smegmatis mc2 155 | MIC = 2400 μg/ml | in vitro | J774 macrophage cell lines | NA | IC50= 11226 μg/ml | NA | NA | Stimulation of TNF-α production | inhibit bacterial Atpase activity | NA | NA | NA | 2015 | 26218806 |
| antitb_1651 | Human neutrohil peptide (HNP-1) | ACYCRIPACIAGERRYGTCIYQGRLWAFCC | Free | Free | Disulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29 | Cyclic | 30 | L | Cationic | Synthetic | Human neutrophil | Mycobacterium Tuberculosis | Mycobacterium tuberculosis H37Rv | IC50 = 0.8μg/ml | in vitro | murine macrophage-like cell line J744A.1 | NA | cytotoxic at above concentration 5 ug/ml | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2016 | 10933095 |
| antitb_1652 | Human neutrohil peptide (HNP-1) | ACYCRIPACIAGERRYGTCIYQGRLWAFCC | Free | Free | Disulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29 | Cyclic | 30 | L | Cationic | Synthetic | Human neutrophil | Mycobacterium Tuberculosis | Mycobacterium tuberculosis H37Rv | IC90 = 2.5 μg/ml | in vitro | murine macrophage-like cell line J744A.1 | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2016 | 10933095 |
| antitb_1653 | NA | WKWLKKWIK | Free | Free | None | Linear | 9 | L | Cationic | Synthetic | NA | Mycobacterium Tuberculosis | Mycobacterium tuberculosis H37Rv | IC90 = 1.5 μg/ml | in vitro | Human THP-1 cell lines | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2016 | 26645944 |
| antitb_1731 | Seq ID No 10 | KMHATNHGGGS | Free | Free | None | Linear | 11 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M13 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
| antitb_1732 | Seq ID No 22 | YPHHFKHRHIPIGGGS | Free | Free | None | Linear | 16 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M14 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
| antitb_1733 | Seq ID No 1 | GVENVSW | Free | Free | None | Linear | 7 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M15 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
| antitb_1734 | Seq ID No 2 | KMHATNH | Free | Free | None | Linear | 7 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M16 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
| antitb_1735 | Seq ID No 9 | KMHATNHGGGS | Free | Free | None | Linear | 11 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M17 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
| antitb_1736 | Seq ID No 21 | YPHHFKHRHIPI | Free | Free | None | Linear | 12 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M18 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
| antitb_1737 | FKAB-1F | KL-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-Oic-KR | Free | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 21 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 30 μM | Both | RBC | NA | 63 % hemolysis at 100 and 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1738 | FKAB-1G | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 14 % hemolysis at 100 and 25 μM | Mice | No observed toxicity at 5 and 25 mg/kg but minor | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1739 | FKAB-1H | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Acetylation | Addition of CONH-CH2-CH2-NH2 | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | NA | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1740 | FKAB-1L | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Acetylation | Addition of CONH-CH2-CH2-CH2-NH2 | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | NA | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1741 | FKAB-1Ga | G-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Free | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 33.4 % hemolysis at 100 μM and 14.3 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1742 | FKAB-1Gb | G-KL-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Free | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 43.6 % hemolysis at 100 μM and 24.9 % at 25 μM | Mice | No observed toxicity at 1, 5 and 25 mg/kg | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1743 | FKAB-1Gc | F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 15 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 30 μM | Both | RBC | NA | 86.8 % hemolysis at 100 μM and 50 % at 25 μM | Mice | Minor weight loss, no observed toxicity at 1, 5 an | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1744 | FKAB-1Gd | Gaba-F-Tic-Oic-Gaba-K-Tic-Oic-Gaba-F-Tic-Oic-Gaba-K-Tic-KKKK | Acetylation | Amidation | Gaba = Gama aminobutyric acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 10.8 % hemolysis at 100 μM and 1.0 % at 25 μM | Mice | Minor weight loss, no observed toxicity at 1, 5 an | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1745 | FKAB-1Ge | G-Tic-Oic-K-Tic-Oic-G-Tic-Oic-K-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 15 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 26.7 % hemolysis at 100 μM and 9.2 % at 25 μM | Mice | No observed toxicity at 1, 5 and 25 mg/kg | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1746 | FKAB-1Gf | GF-Oic-GK-Oic-GF-Oic-GKKKKK | Acetylation | Amidation | Oic = Octahydroindolecarboxylic acid | Linear | 15 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 100 μM | Both | RBC | NA | 5.9 % hemolysis at 100 μM and 3.2 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1747 | FKAB-1Gg | GF-Tic-GK-Tic-GF-Tic-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid | Linear | 16 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 30 μM | Both | RBC | NA | 6 % hemolysis at 100 μM and 4.9 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1748 | FKAB-1Gg1 | GF-Tic-G-GK-Tic-G-GF-Tic-G-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 30 μM | Both | RBC | NA | 5.70 % hemolysis at 100 μM and 3.80 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1749 | FKAB-1Gf1 | GF-G-Oic-GK-G-Oic-GF-G-Oic-GK-G-KKKK | Acetylation | Amidation | Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 100 μM | Both | RBC | NA | 3.30 % hemolysis at 100 μM and 3.3 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1750 | FKAB-1Gh | GF-F-Oic-GK-F-Oic-GF-F-Oic-GK-F-KKKK | Acetylation | Amidation | Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 27.30 % hemolysis at 100 μM and 8.9 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1751 | FKAB-1Gd1 | βAla-F-Tic-Oic-βAla-K-Tic-Oic-βAla-F-Tic-Oic-βAla-K-Tic-KKKK | Acetylation | Amidation | βAla = Beta alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 1 μM | Both | RBC | NA | 24.4 % hemolysis at 100 μM and 7.4 % at 25 μM | Mice | No observed toxicity at 5 and 25 mg/kg but minor w | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1752 | FKAB-1Gd2 | Ahx-F-Tic-Oic-Ahx-K-Tic-Oic-Ahx-F-Tic-Oic-Ahx-K-Tic-KKKK | Acetylation | Amidation | Ahx = 6-amino hexanoic acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 44.7 % hemolysis at 100 μM and 26.6 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1753 | FKAB-1Gc1 | F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-KKKKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 17 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 41.3 % hemolysis at 100 μM and 33.5 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1754 | FKAB-1Gi | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 24.9 % hemolysis at 100 μM and 18.9 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1755 | FKAB-1Gd3 | Gaba-F-Tic-Oic-Gaba-K-Tic-Oic-Gaba-F-Tic-Oic-Gaba-K-Tic-KKKKK | Acetylation | Amidation | Gaba = Gama aminobutyric acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 29.7 % hemolysis at 100 μM and 10.5 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1756 | FKAB-1Gj | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-Orn-Orn-Orn-Orn | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1757 | FKAB-1Go | G-Fpa-Tic-Oic-GK-Tic-Oic-G-Fpa-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Fpa = 4-Fluorophenyl alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1758 | FKAB-1Gp | GF-Tic-Oic-G-Orn-Tic-Oic-GF-Tic-Oic-G-Orn-Tic-Orn-Orn-Orn-Orn | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1759 | FKAB-1Gl | Biotin-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Biotinylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1760 | FKAB-1Gs | GF-Tic-Oic-G-Dpr-Tic-Oic-GF-Tic-Oic-G-Dpr-Tic-Dpr-Dpr-Dpr-Dpr | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Dpr = 2,3-diaminopropanoic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 100 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1761 | FKAB-1Gw | βAla-Fpa-Tic-Oic-βAla-Dpr-Tic-Oic-βAla-Fpa-Tic-Oic-βAla-Dpr-Tic-Dpr-Dpr-Dpr-Dpr- | Acetylation | Amidation | βAla = Beta alanine, Fpa = 4 Fluorophenyl alanine Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 100 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1762 | FKAB-1G2 | G-dF-Tic-Oic-GK-Tic-Oic-G-dF-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | Mix | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1763 | FKAB-1G3 | GF-Tic-Oic-G-dK-Tic-Oic-GF-Tic-Oic-G-dK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | Mix | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1764 | FKAB-1Go2 | G-Nph-Tic-Oic-GK-Tic-Oic-G-Nph-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Nph = 4-Nitrophneylalanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |