Prediction of Toxic Regions in a Protein

This page is designed for assisting users in identification of highly toxic regions is a given protein sequence. This tool predic regions in a protein, which are contributing in toxicity, which may be further removed or altered. The other way round, here users can also search a protein sequence to find out novel toxic peptides. It will generate the fragments of length selected by the users and predict their toxicity along with important physico-chemical properties like hydrophobicity, charge pI etc. For more information click Help.

Type or paste protein sequence in single letter code:


Choose peptide fragment length:    

Select prediction method: SVM (Swiss-Prot) based   SVM (Swiss-Prot) + Motif based   SVM (TrEMBL) based   SVM (TrEMBL) + Motif based      

OR

Select Quantitative Matrix (QM) method: Monopeptide(Swiss-Prot)   Monopeptide (TrEMBL)  Dipeptide (Swiss-Prot)   Dipeptide (TrEMBL)      


Choose E-value cut-off for motif based method:    

Choose SVM threshold:    

Physicochemical Properties to Be Displayed
 Hydrophobicity     Sterichinderance     Side bulk     Hydropathicity     Amphipathicity     Hydrophilicity     Net Hydrogen   
 Charge  pI     Molecular weight  All

Show Results:   Tabular     Graphically