| Primary information |
|---|
| ID | 1847 |
| ThPP ID | Th1235 |
| Therapeutic Peptide/Protein Name | Protein S human |
| Sequence | ANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRS view full sequnce in fasta |
| Functional Classification | Ib |
| Molecular Weight | 69000 |
| Chemical Formula | NA |
| Isoelectric Point | 5.0-5.5 (7 |
| Hydrophobicity | NA |
| Melting Point (℃) | NA |
| Half Life | NA |
| Description | Protein S (also known as S-Protein) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene. |
| Indication/Disease | To prevent coagulation and stimulating fibrinolysis |
| Pharmacodynamics | NA |
| Mechanism of Action | Cofactor for activated protein C |
| Toxicity | NA |
| Metabolism | NA |
| Absorption | NA |
| Volume of Distribution | NA |
| Clearance | NA |
| Categories | Anticoagulant plasma protein |
| Patents Number | NA |
| Date of Issue | NA |
| Date of Expiry | NA |
| Drug Interaction | NA |
| Target | NA |
| Information of corresponding available drug in the market |
|---|
| Brand Name | Protein S human |
| Company | NA |
| Brand Discription | Protein S is a single chain vitamin K-dependent protein which is thought to function in both the coagulation and complement cascades (1,2). Approximately 60% of protein S circulating in plasma is complexed to C4b binding protein (C4BP). It has been suggested that g-carboxyglutamic acid (gla) dependent binding of protein S to negatively charged phospholipids may function to concentrate C4BP at cell surfaces following injury. |
| Prescribed for | In the coagulation system, protein S functions as an anticoagulant cofactor protein |
| Chemical Name | NA |
| Formulation | Purified protein S is supplied in 50% (vol/vol) glycerol/H2O |
| Physcial Appearance | Solid |
| Route of Administration | NA |
| Recommended Dosage | NA |
| Contraindication | NA |
| Side Effects | NA |
| Useful Link | http://www.haemtech.com/products/cofactors/protein-s , http://www.abcam.com/natural-human-protein-s-ab184880.html , http://www.enzymeresearch.com/product/human-protein-s/ |
| PubMed ID | 836809 |
| 3-D Structure | N.A. |