==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb

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Th1053 details
Primary information
ID1365
ThPP IDTh1053
Therapeutic Peptide/Protein NameSerum albumin iodonated
SequenceMKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA view full sequnce in fasta
Functional ClassificationIV
Molecular Weight66472.2
Chemical FormulaC2936H4624N786O889S41
Isoelectric Point5.67
Hydrophobicity-0.395
Melting Point (℃)62
Half LifeN.A.
DescriptionA diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following Intravenous infusion, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times
Indication/DiseaseFor determination of total blood and plasma volumes
PharmacodynamicsRegulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of ActionSerum albumin acts as a high molecular weight, very soluble osmolyte.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesDiagnostic Agents
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionN.A.
TargetApolipoprotein E,Serum amyloid A-1 protein,Protein AMBP
Information of corresponding available drug in the market
Brand NameMegatope
CompanyIsoTex Diagnostics
Brand DiscriptionMegatope (Iodinated I 131 Albumin Injection) is a diagonostic radiopharmaceutical containing iodinated I 131 albumin. Megatope was prepared from blood that was nonreactive when tested for hepatitis
Prescribed forMegatope (Iodinated I 131 Albumin Injection) is indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times, and in protein turnover studies, heart and great vessel,dilineation, localization of the placenta, and localization of celebral neospasms
Chemical NameN.A.
FormulationEach mL of sterile, nonpyrogenic, aqueous, colorless to very pale yellow solution provides approximate 10 mg, protein (albumin human), 16 mg dibasic sodium phosphate, 1.6 mg monobasic, sodium phosphate, not more than 0.4 guanidine hydrochloride, sodium chloride, for isotonicity, and 9 mg benzyl alcohol as a preservative.
Physcial AppearanceMegatope (Iodinated I 131 Albumin Injection) may be colorless to very pale yellow solution
Route of AdministrationInjection for Intravenous administration
Recommended DosageThe total dosage administered in any one week should not exceed 200 microcuries
ContraindicationNone Known.
Side EffectsAlthough the immunological properties of albumin human are believed to be virtually unaltered by the iodination process, there is a theoretical possibility that allergic reactions may occur in patients receiving additional doses a number of weeks after an initial dose.
Useful Linkhttp://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=62ca4278-8cc9-46b7-8f3c-303ce6a9c155
PubMed ID17139284, 17016423
3-D StructureTh1053 (View) or (Download)
Primary information
ID1366
ThPP IDTh1053
Therapeutic Peptide/Protein NameSerum albumin iodonated
SequenceMKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA view full sequnce in fasta
Functional ClassificationIV
Molecular Weight66472.2
Chemical FormulaC2936H4624N786O889S41
Isoelectric Point5.67
Hydrophobicity-0.395
Melting Point (℃)62
Half LifeN.A.
DescriptionA diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following Intravenous infusion, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times
Indication/DiseaseFor determination of total blood and plasma volumes
PharmacodynamicsRegulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of ActionSerum albumin acts as a high molecular weight, very soluble osmolyte
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesDiagnostic Agents
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionRilonacept results in increased immunosuppressive effects; increases the risk of infection
TargetN.A.
Information of corresponding available drug in the market
Brand NameJeanotope
CompanyIsoTex Diagnostics
Brand DiscriptionJeanotope I-125 was prepared from the blood that was non-reactive when tested for hepatitis B surface antigen (HBsAg) and HIV antibody.
Prescribed forJeanotope I-125 is indicated for use in the determination of total blood and plasma volume.
Chemical NameN.A.
FormulationEach milliliter provides approximately 10 mg protein (normal human serum albumin), 1.6 mg sodium phosphate, 16 mg sodium biphosphate, not more than 0.4 mg guanidine hydrochloride, sodium chloride for isotonicity, and 9 mg benzyl alcohol as a preservative. The stabilizer aceryltryptophanate and sodium caprylate have a concentration of less, than 0.0089M.
Physcial AppearanceJeanatope 1-125 (Iodinated 1-125 Albumin Injection) is a Sterile, nonpyrogenic, aqueos solution
Route of AdministrationIntravenous infusion
Recommended DosageWhen a procedure such as a blood volume determination is to be repeated, the total dosage administered in any one week should not exceed 7.4 megabecquerels, (200 microcuries).
ContraindicationAt present there are no known contraindications to the use of this preparation
Side EffectsAlthough the immunological properties of albumin human are believed to be virtually unaltered by the iodination process, there is a theoretical possibility that allergic reactions may occur in patients receiving additional doses a number of weeks after an initial dose.
Useful Linkhttp://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7b6f6a5e-f456-4db9-a3da-44d870ee6547
PubMed ID17139284, 17016424
3-D StructureTh1053 (View) or (Download)
Primary information
ID1367
ThPP IDTh1053
Therapeutic Peptide/Protein NameSerum albumin iodonated
SequenceMKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA view full sequnce in fasta
Functional ClassificationIV
Molecular Weight66472.2
Chemical FormulaC2936H4624N786O889S41
Isoelectric Point5.67
Hydrophobicity-0.395
Melting Point (℃)62
Half LifeN.A.
DescriptionA diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following Intravenous infusion, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times
Indication/DiseaseFor determination of total blood and plasma volumes
PharmacodynamicsRegulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of ActionSerum albumin acts as a high molecular weight, very soluble osmolyte
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesDiagnostic Agents
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameVolumex
CompanyIsoTex Diagnostics
Brand DiscriptionVolumex (Iodinated I 131 Albumin Injection) is a diagnostic radiopharmaceutical containing iodinated I 131 albumin. Volumex was prepared from blood that was nonreactive when tested for hepatitis B surface antigen (HBsAg).
Prescribed forVolumex (Iodinated I 131 Allbumin injection) is indicated for use in determination of total blood and plasma volumes and in protein turnover studies
Chemical NameN.A.
FormulationEach ml of nonpyrogenic, aqueous, colorless to very pale yellow solution provides approximately 10 mg protein (albumin human), 16 mg dibasic sodium phosphate, 1.6 mg monobasic sodium phosphate, not more, than 0.4 mg guanidine hydrochloride, sodium chloride for isotonicity, and 9 mg benzyl alcohol as a preservative.
Physcial AppearanceVolumex (Iodinated I 131 Albumin Injection) may be colorless to very pale yellow solution.
Route of AdministrationIntravenous infusion
Recommended DosageWhen a procedure such as a blood volume determination is to be repeated, the total dosage administered in any one week should not exceed 200 microcuries
ContraindicationNone Known.
Side EffectsAlthough the immunological properties of albumin human are believed to be virtually unaltered by the iodination process, there is a theoretical possibility that allergic reactions may occur in patients receiving additional doses a number of weeks after an initial dose.
Useful Linkhttp://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=812240e4-fc28-46c2-92f3-1ba4e029645a
PubMed ID17139284, 17016425
3-D StructureTh1053 (View) or (Download)