==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

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Th1051 details
Primary information
ID1361
ThPP IDTh1051
Therapeutic Peptide/Protein NameHuman Serum Albumin
SequenceMKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA view full sequnce in fasta
Functional ClassificationIa
Molecular Weight66472.2
Chemical FormulaC2936H4624N786O889S41
Isoelectric Point5.67
Hydrophobicity-0.395
Melting Point (℃)62
Half LifeN.A.
DescriptionHuman serum albumin isolated from expired blood plasma.
Indication/DiseaseHuman Serum Albumin is indicated for treatment of severe blood loss, hypervolemia, hypoproteinemia.
PharmacodynamicsHuman Serum Albumin regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of ActionHuman Serum albumin acts as a high molecular weight, very soluble osmolyte.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesSerum substitutes
Patents NumberUS6723303
Date of Issue21/04/05
Date of Expiry21/04/25
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameAlbuminar
CompanyCSL Behring
Brand DiscriptionAlbuminar is a sterile aqueous solution of albumin obtained from large pools of adult human venous plasmaby low temperature controlled fractionation according to the Cohn process. It is stabilized with 0.02 M sodium acetyltryptophanate and 0.02 M sodium caprylate and pasteurized at 60 for 10 hours.
Prescribed forprecscribed in treatment of Shock, Burns, Hypoproteinemia with or without edema
Chemical NameN.A.
FormulationAlbumin (Human) 25% (albumin human) is a solution containing in each 100 mL, 25 grams of serum albumin, osmotically equivalent to 500 mL of normal human plasma. The pH of the solution is adjusted with sodium bicarbonate, sodium hydroxide, or acetic acid. Approximate concentrations of significant electrolytes per liter are: sodium - 130-160 mEq; and potassium - n.m.t. 1 mEq.
Physcial AppearanceAlbumin (Human) 25%, is a Sterile aqueous solution of albumin obtained from large pools of adult human venous plasma by low temperature controlled fractionation according to the Cohn process.
Route of AdministrationAlbumin (Human) 25%, Albuminar-25 (albumin human)
Recommended DosageAlbumin (Human) 25%, Albuminar-25 (albumin (human)) may be given intravenously without dilution or it may be diluted with normal saline or 5% dextrose before administration. 200 mL per liter gives a solution which is approximately isotonic and iso-osmotic with citrated plasma.
ContraindicationAlbumin (Human) 25% may be contraindicated in patients with severe anemia or cardiac failure and in patients with a history of allergic reactions to human albumin.
Side EffectsAllergic or pyrogenic reactions are characterized primarily by fever and chills; rash, nausea, vomiting, tachycardia and hypotension have also been reported. if administered rapidly, may result in vascular overload with resultant pulmonary edema.
Useful Linkhttp://www.rxlist.com/albuminar-drug.htm
PubMed ID12846933, 9675210
3-D StructureTh1051 (View) or (Download)
Primary information
ID1362
ThPP IDTh1051
Therapeutic Peptide/Protein NameHuman Serum Albumin
SequenceMKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA view full sequnce in fasta
Functional ClassificationIa
Molecular Weight66472.2
Chemical FormulaC2936H4624N786O889S41
Isoelectric Point5.67
Hydrophobicity-0.395
Melting Point (℃)62
Half LifeN.A.
DescriptionHuman serum albumin isolated from expired blood plasma.
Indication/DiseaseHuman Serum Albumin is indicated for treatment of severe blood loss, hypervolemia, hypoproteinemia.
PharmacodynamicsHuman Serum Albumin regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of ActionHuman Serum albumin acts as a high molecular weight, very soluble osmolyte.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesSerum substitutes
Patents NumberUS5558094
Date of Issue01/03/99
Date of Expiry29/02/16
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameAlbutein
CompanyGRIFOLS
Brand DiscriptionAlbutein is a concentrate of plasma proteins from human blood. It works by increasing plasma volume or serum albumin levels.
Prescribed forFor treatment of hypovolemic shock,As an adjunct in hemodialysis for patients undergoing long-term dialysis or for those patients who are fluid-overloaded and cannot tolerate substantial volumes of salt solution for therapy of shock or hypotension
Chemical NameN.A.
FormulationAlbutein 20% is clinically desirable, compatible diluents include sterile 0.9% Sodium Chloride solution or sterile 5% Dextrose in Water.
Physcial AppearanceAlbutein 20% is a Sterile, aqueous solution for single dose intravenous administration containing 20% human albumin (weight/volume).
Route of AdministrationAlbutein 20% is to be administered by the Intraven
Recommended DosageAlbutein 20% is administered intravenously. The total dosage will vary with the individual. In adults, an initial infusion of 100 mL is suggested. 
ContraindicationAlbutein 20% is contraindicated in patients with severe anemia or cardiac failure in the presence of normal or increased intravascular volume.
Side EffectsThe most common adverse reactions include fever and chills, rash, nausea, vomiting, tachycardia and hypotension. Should an adverse reaction occur, slow or stop the infusion for a short period of time which may result in the disappearance of the symptoms. If administration has been stopped and the patient requires additional Albutein 20%, material from a different lot should be used.
Useful LinkPeters, T., Jr., Serum Albumin in: The Plasma Proteins, 2nd Ed., Putnam F.W. (ed), New York, Academic Press, 1:133-181, 1975. Finlayson, J.S., Albumin Products Semin Thromb Hemo, 6:85-120, 1980.
PubMed ID12846933, 9675210
3-D StructureTh1051 (View) or (Download)