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Th1030 details
Primary information
ID1226
ThPP IDTh1030
Therapeutic Peptide/Protein NameInterferon gamma-1b
SequenceCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQS view full sequnce in fasta
Functional ClassificationIb
Molecular Weight17145.6
Chemical FormulaC761H1206N214O225S6
Isoelectric Point9.54
Hydrophobicity-0.823
Melting Point (℃)61
Half LifeN.A.
DescriptionHuman Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
Indication/DiseaseTo treat Chronic granulomatous disease and Osteopetrosis.
PharmacodynamicsIFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon gamma-1b may prevent excessive scarring.
Mechanism of ActionIt binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesImmunosuppressive Agents
Patents NumberUS6936695
Date of Issue30/08/05
Date of Expiry30/08/22
Drug InteractionN.A.
TargetInterferon gamma receptor 1,Interferon gamma receptor 2
Information of corresponding available drug in the market
Brand NameActimmune
CompanyInterMune Inc
Brand DiscriptionACTIMMUNE, a biologic response modifier, is a single-chain polypeptide containing 140 amino acids. Production is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purifi
Prescribed forUsed for reducing the number and severity of infections associated with chronic granulomatous disease. It is also used to delay the progression of severe, life-threatening bone density disease
Chemical NameN.A.
FormulationEach 0.5 mL of ACTIMMUNE contains 100 mcg (2 million IU) of Interferon gamma-1 b formulated in 20 mg mannitol, 0.36 mg sodium succinate, 0.05 mg polysorbate 20 and Sterile Water for Injection.
Physcial AppearanceSterile, clear, colorless solution
Route of AdministrationSubcutaneous Injection
Recommended DosageDose for the treatment of patients with Chronic Granulomatous Disease and severe, malignant osteopetrosis is 50 mcg/m2(1 million IU/m2) for patients whose body surface area is greater than 0.5 m2 and 1.5 mcg/kg/dose for patients whose body surface area is equal to or less than 0.5 m2.
ContraindicationHypersensitivity
Side EffectsDiarrhea; fatigue; flu-like symptoms (eg, low-grade fever, chills, general body discomfort); headache; joint pain; muscle pain; nausea; pain, redness, or swelling at the injection site; tiredness; vomiting; weakness. Severe side efects include Severe dizziness and troubled breathing.
Useful Linkhttp://www.drugs.com/cdi/actimmune.html
PubMed ID25470089, 25335475, 24576196, 19570573, 18644457, 18314182, 17128525, 16637863, 16611657
3-D StructureTh1030 (View) or (Download)
Primary information
ID1227
ThPP IDTh1030
Therapeutic Peptide/Protein NameInterferon gamma-1b
SequenceCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQS view full sequnce in fasta
Functional ClassificationIb
Molecular Weight17145.6
Chemical FormulaC761H1206N214O225S6
Isoelectric Point9.54
Hydrophobicity-0.823
Melting Point (℃)61
Half LifeN.A.
DescriptionHuman Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
Indication/DiseaseTo treat Chronic granulomatous disease and Osteopetrosis.
PharmacodynamicsIFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon gamma-1b may prevent excessive scarring.
Mechanism of ActionIt binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesImmunosuppressive Agents
Patents NumberUS6936694
Date of Issue30/08/05
Date of Expiry30/08/22
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameN.A.
CompanyN.A.
Brand DiscriptionN.A.
Prescribed forN.A.
Chemical NameN.A.
FormulationN.A.
Physcial AppearanceN.A.
Route of AdministrationN.A.
Recommended DosageN.A.
ContraindicationN.A.
Side EffectsN.A.
Useful Linkhttp://www.drugs.com/drug-interactions/interferon-gamma-1b,actimmune-index.html
PubMed ID25470089, 25335475, 24576196, 19570573, 18644457, 18314182, 17128525, 16637863, 16611657
3-D StructureTh1030 (View) or (Download)
Primary information
ID1228
ThPP IDTh1030
Therapeutic Peptide/Protein NameInterferon gamma-1b
SequenceCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQS view full sequnce in fasta
Functional ClassificationIb
Molecular Weight17145.6
Chemical FormulaC761H1206N214O225S6
Isoelectric Point9.54
Hydrophobicity-0.823
Melting Point (℃)61
Half LifeN.A.
DescriptionHuman Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
Indication/DiseaseTo treat Chronic granulomatous disease and Osteopetrosis.
PharmacodynamicsIFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon gamma-1b may prevent excessive scarring.
Mechanism of ActionIt binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesImmunosuppressive Agents
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameN.A.
CompanyN.A.
Brand DiscriptionN.A.
Prescribed forN.A.
Chemical NameN.A.
FormulationN.A.
Physcial AppearanceN.A.
Route of AdministrationN.A.
Recommended DosageN.A.
ContraindicationN.A.
Side EffectsN.A.
Useful Linkhttp://www.rxlist.com/actimmune-drug.htm
PubMed ID25470089, 25335475, 24576196, 19570573, 18644457, 18314182, 17128525, 16637863, 16611657
3-D StructureTh1030 (View) or (Download)