==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

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1826 details
Primary information
ThPP IDTh1216
Therapeutic Peptide/Protein NameAnthrax immune globulin human
SequenceNA view full sequnce in fasta
Functional ClassificationIIa
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24.3 days
DescriptionAnthrax immune globulin is a human immune globulin that is used in combination with antibiotics to treat anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing polyclonal antibodies that bind the protective antigen (PA) component of Bacillus anthracis lethal and edema toxins. This binding of antibody to PA prevents PA-mediated cellular entry of toxic factors. It is administered in combination with appropriate antibiotic therapy as the immunoglobulin itself is not known to have direct antibacterial activity against anthrax bacteria, which otherwise may continue to grow and produce anthrax toxins.
Indication/DiseaseAnthrax immune globulin is indicated for the treatment of inhalational anthrax in adult and pediatric patients in combination with appropriate antibacterial drugs.
PharmacodynamicsNA
Mechanism of ActionPolyclonal anthrax immune globulin is a passive immunizing agent that neutralizes anthrax toxin by binding to Protective Antigen (PA) to prevent PA-mediated cellular entry of anthrax edema factor and lethal factor. It is administered in combination with appropriate antibiotic therapy as the immunoglobulin itself is not known to have direct antibacterial activity against anthrax bacteria, which otherwise may continue to grow and produce anthrax toxins.
ToxicityThe most common adverse reactions to Anthrasil observed in >5% of healthy volunteers in clinical trials were headache, infusion site pain and swelling, nausea, and back pain.
MetabolismNA
AbsorptionPeak levels were reached immediately after infusion and then declined over the duration of study (84 days). Mean activity remained above the lower limit of quantitation (5 milliunits per mL) over the entire 84-day post-dose period for the three doses studied. Cmax was found to be 83.0 mU/mL while Tmax was found to be 0.116 days.
Volume of Distribution5714.8 mL
Clearance174.2 mL/day
CategoriesPlasma derivative
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionBazedoxifene may increase the thrombogenic activities of Anthrax immune globulin human.; Chlorotrianisene may increase the thrombogenic activities of Anthrax immune globulin human; Conjugated Equine Estrogens may increase the thrombogenic activities of Anthrax immune globulin human; Dienestrol may increase the thrombogenic activities of Anthrax immune globulin human; Diethylstilbestrol may increase the thrombogenic activities of Anthrax immune globulin human; Estradiol may increase the thrombogenic activities of Anthrax immune globulin human; Estriol may increase the thrombogenic activities of Anthrax immune globulin human; Estrone may increase the thrombogenic activities of Anthrax immune globulin human; Ethinyl Estradiol may increase the thrombogenic activities of Anthrax immune globulin human; Genistein may increase the thrombogenic activities of Anthrax immune globulin human.
TargetProtective antigen
Information of corresponding available drug in the market
Brand NameANTHRASIL
CompanyCangene Corporation
Brand DiscriptionAnthrax immune globulin belongs to a group of medicines known as immunizing agents.
Prescribed forIt is indicated for the treatment of inha lational anthrax in adult and pediatric patients in 35 combination with appropriate antibacterial drugs
Chemical NameNA
Formulation60 [iU]/35mL
Physcial AppearnceLiquid
Route of AdministrationIntravenous
Recommended DosageThe initial dose of ANTHRASIL for the treatment of inhalational anthrax in adults in combination with appropriate antimicrobial therapy is 420 units
ContraindicationHistory of anaphylactic or severe systemic reaction to human immune globulins
Side EffectsHypersensitivity reactions including anaphylaxis
Useful Linkhttps://www.drugs.com/cons/anthrasil.html , https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM439812.pdf
PubMed ID23979731
3-D StructureN.A.