A database of FDA approved therapeutic peptides and proteins
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1800 details |
| Primary information | |
|---|---|
| ThPP ID | Th1194 |
| Therapeutic Peptide/Protein Name | Tuberculin Purified Protein Derivative |
| Sequence | NA view full sequnce in fasta |
| Functional Classification | IV |
| Molecular Weight | NA |
| Chemical Formula | NA |
| Isoelectric Point | NA |
| Hydrophobicity | NA |
| Melting Point (℃) | NA |
| Half Life | NA |
| Description | Aplisol (tuberculin PPD, diluted) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The solution is stabilized with polysorbate (Tween) 80, buffered with potassium and sodium phosphates and contains 0.25% phenol as a preservative. The purified protein fraction is isolated from culture media filtrates of a human strain of Mycobacterium tuberculosis. |
| Indication/Disease | Used in the detection of infection with Mycobacterium tuberculosis. |
| Pharmacodynamics | |
| Mechanism of Action | NA |
| Toxicity | NA |
| Metabolism | NA |
| Absorption | NA |
| Volume of Distribution | NA |
| Clearance | NA |
| Categories | NA |
| Patents Number | NA |
| Date of Issue | NA |
| Date of Expiry | NA |
| Drug Interaction | NA |
| Target | NA |
| Information of corresponding available drug in the market | |
| Brand Name | Aplisol |
| Company | Par Pharmaceutical, Inc. |
| Brand Discription | Aplisol is a diagnostic agent. It works by causing a mild, delayed allergic reaction in patients infected with TB or who have had a past infection, which allows for detection of TB. |
| Prescribed for | Detecting tuberculosis (TB) infection. |
| Chemical Name | |
| Formulation | The solution is stabilized with polysorbate (Tween) 80, buffered with potassium and sodium phosphates and contains approximately 0.35% phenol as a preservative. |
| Physcial Appearnce | solution for injection |
| Route of Administration | intradermal |
| Recommended Dosage | Diagnosis: Mantoux test, inject 0.1 mL (5 tuberculin units) intradermally; the result is read 48 to 72 hours after administration |
| Contraindication | Previous positive tuberculin skin test responsiveness suppressed within 6 weeks of viral infection, inactive TB, immunosuppression, geriatric |
| Side Effects | Commonside effect include Pain, itching, or redness at the injection site. Sever side effect mmay occur Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blisters; open sores. |
| Useful Link | http://www.druglib.com/druginfo/aplisol/description_pharmacology/ |
| PubMed ID | 27852999, 27835944, 27279304, 26295565, 26267100, 26026065, 25256774, 25101086, 25037701 |
| 3-D Structure | N.A. |