Primary information |
---|
ThPP ID | Th1188 |
Therapeutic Peptide/Protein Name | Hyaluronidase (Human Recombinant) |
Sequence | NA view full sequnce in fasta |
Functional Classification | Ib |
Molecular Weight | 61000 |
Chemical Formula | NA |
Isoelectric Point | NA |
Hydrophobicity | NA |
Melting Point (℃) | NA |
Half Life | NA |
Description | A purified preparation of the enzyme recombinant human hyaluronidase. Hyaluronidase (Human Recombinant) is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragment of human hyaluronidase (PH20). The purified hyaluronidase glycoprotein contains 447 amino acids with an approximate molecular weight of 61,000 Daltons. |
Indication/Disease | Indicated as an adjuvant to increase the absorption and dispersion of other injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous urography for improving resorption of radiopaque agents. |
Pharmacodynamics | Hyaluronidase hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. Hyaluronidase is used for enhancing absorption and distribution of other injected drugs. |
Mechanism of Action | The family of hyaluronidase enzymes hydrolyzes hyaluronic acid (a glucoseaminoglycan) which is a major constituent of the interstitial barrier. Hyaluronidase (Human Recombinant) is a highly purified recombinant human hyluronidase which lowers the viscosity of the interstitial barrier by breaking down hyaluronic acid and is under investigation as a chemoadjuvant to facilitate local interstitial drug delivery as well as increase bioavilability. |
Toxicity | NA |
Metabolism | NA |
Absorption | NA |
Volume of Distribution | NA |
Clearance | NA |
Categories | NA |
Patents Number | US7767429 |
Date of Issue | 23/09/07 |
Date of Expiry | 23/09/27 |
Drug Interaction | NA |
Target | Hyaluronan; Transforming growth factor beta-1 |
Information of corresponding available drug in the market |
---|
Brand Name | NA |
Company | NA |
Brand Discription | NA |
Prescribed for | NA |
Chemical Name | NA |
Formulation | NA |
Physcial Appearnce | NA |
Route of Administration | NA |
Recommended Dosage | NA |
Contraindication | NA |
Side Effects | NA |
Useful Link | http://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm |
PubMed ID | 16876899, 17683255 |
3-D Structure | N.A. |