==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb

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1779 details
Primary information
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of DistributionNA
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameWinrho Sdf (liquid Formulation)
CompanyAptevo Biotherapeutics Llc
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation15000 unit
Physcial Appearnceliquid
Route of Administrationintramuscular; intravenous
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.