A database of FDA approved therapeutic peptides and proteins
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1771 details |
| Primary information | |
|---|---|
| ThPP ID | Th1186 |
| Therapeutic Peptide/Protein Name | Human rabies virus immune globulin |
| Sequence | NA view full sequnce in fasta |
| Functional Classification | IIIa |
| Molecular Weight | NA |
| Chemical Formula | NA |
| Isoelectric Point | NA |
| Hydrophobicity | NA |
| Melting Point (℃) | NA |
| Half Life | NA |
| Description | NA |
| Indication/Disease | It is indicated for individuals suspected of exposure to rabies, particularly severe exposure, with one exception: persons who have been previously immunized with HDCV Rabies Vaccine in a pre-exposure or postexposure treatment series should receive only vaccine. |
| Pharmacodynamics | NA |
| Mechanism of Action | It provides passive protection by neutralizing the rabies virus when given to individuals exposed to rabies virus. When a rabies immune globulin dose of 20 IU/kg was given simultaneously with the first dose of rabies vaccine, levels of passive anti-rabies antibody were detected 24 hours after injection in all individuals. There was minimal or no interference with the immune response to the initial and subsequent doses of rabies vaccine, including booster doses. |
| Toxicity | NA |
| Metabolism | NA |
| Absorption | NA |
| Volume of Distribution | NA |
| Clearance | NA |
| Categories | NA |
| Patents Number | NA |
| Date of Issue | NA |
| Date of Expiry | NA |
| Drug Interaction | Live virus vaccines, such as measles vaccine, should not be given for four months following Human rabies virus immune globulin administration because antibodies in the immune globulin preparation may interfere with the immune response to the vaccine. |
| Target | NA |
| Information of corresponding available drug in the market | |
| Brand Name | Imogam Rabies Pasteurized |
| Company | Sanofi Pasteur Limited |
| Brand Discription | IMOGAM® Rabies Pasteurized [Rabies Immune Globulin (RIG), Pasteurized (Human)] is a sterile solution of antirabies immune globulins (10-16% protein) for intramuscular administration. |
| Prescribed for | It is indicated for post-exposure prophylaxis in persons suspected of exposure to rabies, who have not previously received a complete immunization regimen with a cell culture produced rabies vaccine. |
| Chemical Name | |
| Formulation | Human proteins (100-160 mg) containing IgG-class human rabies immune globulins with a minimum titre of 150 IU/mL. Supplied in 2 mL vial s (300 IU) and 10 mL vials (1,500 IU). |
| Physcial Appearnce | Solution |
| Route of Administration | intramuscular |
| Recommended Dosage | The recommended dose of IMOGAM® Rabies Pasteurized is 20 IU/kg (0.133 mL/kg) of body weight at the time of administration of the first dose of rabies vaccine. |
| Contraindication | IMOGAM® Rabies Pasteurized should not be administered as repeat doses once rabies vaccination has been in itiated. Repeating the dose may interfere with maximum active immunity expected to develop from the rabies vaccine. |
| Side Effects | Hypotension, Tachycardia, Nausea, Vomiting, Local reaction, Fever, chills, Allergic type reaction, Anaphylactic shock, General prurit, Rash |
| Useful Link | https://www.vaccineshoppecanada.com/document.cfm?file=imogam_rabies_e.pdf |
| PubMed ID | 10675760 |
| 3-D Structure | N.A. |