| Primary information |
|---|
| ThPP ID | Th1143 |
| Therapeutic Peptide/Protein Name | Fibrinolysin aka plasmin |
| Sequence | Fibrinolysin heavy chainDLLDDYVNTQGASLLSLSRKNLAGRS view full sequnce in fasta |
| Functional Classification | Ic |
| Molecular Weight | 88400 |
| Chemical Formula | C3848H5912N1096O1185S60 |
| Isoelectric Point | N.A. |
| Hydrophobicity | N.A. |
| Melting Point (℃) | N.A. |
| Half Life | 24 hrs |
| Description | Derived from bovine plasma or extracted from bacterial cultures. It is a globular protein with a molecular weight of ~90 kDa. Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27 kDa and contains the active center of fibrinolysin; the heavy chain has a molecular weight of approximately 57 kDa. It is used as a local healing ointment when combined with the enzyme deoxyribonuclease I (derived from bovine pancreas). Fibrinolysin and deoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (Biological Unit) fibrinolysin and 666 BUs deoxyribonuclease per gram. The ointment (Fibrolan) is marketed by Pfizer in a variety of countries is currently not approved in the USA. |
| Indication/Disease | Fibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas. |
| Pharmacodynamics | N.A. |
| Mechanism of Action | Fibrinolysin attacks and inactivates fibrin molecules occurring in undesirable exudates on the surface of the human body and on human mucosa, e.g., in superficial wounds and burns, while desoxyribonuclease targets and destroys (human) DNA. The combination of the two enzymes has a synergistic effect on necrotic but not on living tissue. |
| Toxicity | N.A. |
| Metabolism | local inactivation. |
| Absorption | N.A. |
| Volume of Distribution | N.A. |
| Clearance | N.A. |
| Categories | N.A. |
| Patents Number | US3234106 |
| Date of Issue | 13/03/66 |
| Date of Expiry | 13/03/86 |
| Drug Interaction | N.A. |
| Target | N.A. |
| Information of corresponding available drug in the market |
|---|
| Brand Name | Elase |
| Company | N.A. |
| Brand Discription | N.A. |
| Prescribed for | N.A. |
| Chemical Name | N.A. |
| Formulation | N.A. |
| Physcial Appearnce | N.A. |
| Route of Administration | N.A. |
| Recommended Dosage | N.A. |
| Contraindication | N.A. |
| Side Effects | N.A. |
| Useful Link | http://en.wikipedia.org/wiki/Fibrinolysin http://www.drugs.com/international/fibrinolysin.html |
| PubMed ID | 6226244 |
| 3-D Structure | Th1143 Heavy chianor (Download)Th1143 Light chian (View) or (Download) |
Th1191 Heavy chianor (Download)Th1191 Light chian (View) or (Download) |