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1445 details
Primary information
ThPP IDTh1079
Therapeutic Peptide/Protein NameSerum albumin
SequenceDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFA view full sequnce in fasta
Functional ClassificationIV
Molecular Weight66472.2
Chemical FormulaC2936H4624N786O889S41
Isoelectric Point5.67
Hydrophobicity-0.395
Melting Point (℃)62
Half LifeN.A.
DescriptionSuspension of microspheres of human serum albumin with perflutren. Perflutren is a highly fluorinated small molecule, used to enhance contrast for ultrasound imaging procedures.
Indication/DiseaseFor treatment of severe blood loss, hypervolemia, hypoproteinemia.
PharmacodynamicsSerum albumin is a soluble, monomeric protein necessary for maintaining and regulating the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentration and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of ActionSerum albumin acts as a high molecular weight, very soluble osmolyte. Serum albumin also acts as a protein drug carrier in plasma, and transports hemin, steroids, thyroid hormones and fatty acids. It binds many other substances, such as unconjugated bilirubin, calcium ions, and other fat soluble hormones.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesSerum substitutes
Patents NumberUS6723303
Date of Issue21/04/05
Date of Expiry21/04/25
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameAlbunex
CompanyMallinckrodt; Tyco Healthcare
Brand DiscriptionAlbumin is used to replace blood volume loss resulting from trauma such as a severe burns or an injury that causes blood loss. This medicine is also used to treat low albumin levels caused by surgery, dialysis, abdominal infections, liver failure, pancreatitis, respiratory distress, bypass surgery, ovarian problems caused by fertility drugs, and other many other conditions.
Prescribed forN.A.
Chemical NameN.A.
FormulationAlbumin 25% may be given intravenously without dilution or it may be diluted with normal saline or 5% dextrose before administration (200 mL per liter gives a solution which is approximately isotonic and iso-osmotic with citrated plasma).
Physcial AppearnceN.A.
Route of AdministrationN.A.
Recommended DosageN.A.
ContraindicationN.A.
Side EffectsN.A.
Useful LinkN.A.
PubMed ID25895349, 25755577, 12846933, 9675210, 17667792
3-D StructureTh1079 (View) or (Download)